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dc.creatorParipović, Dušan
dc.creatorKotur-Stevuljević, Jelena
dc.creatorVukašinović, Aleksandra
dc.creatorIlisić, Tamara
dc.creatorMiloševski-Lomić, Gordana
dc.creatorPeco-Antić, Amira
dc.date.accessioned2019-09-02T12:05:55Z
dc.date.available2019-09-02T12:05:55Z
dc.date.issued2018
dc.identifier.issn0036-5513
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3144
dc.description.abstractOxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175079/RS//
dc.rightsrestrictedAccess
dc.sourceScandinavian Journal of Clinical and Laboratory Investigation
dc.subjectAmbulatory blood pressure monitoringen
dc.subjectleft ventricular hypertrophyen
dc.subjectoxidative stressen
dc.subjecthypertensionen
dc.subjectobesityen
dc.titleThe influence of oxidative stress on cardiac remodeling in obese adolescentsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИлисић, Тамара; Париповић, Душан; Котур-Стевуљевић, Јелена; Пецо-Aнтић, Aмира; Вукашиновић, Aлександра; Милошевски-Ломић, Гордана;
dc.citation.volume78
dc.citation.issue7-8
dc.citation.spage595
dc.citation.epage600
dc.citation.other78(7-8): 595-600
dc.citation.rankM23
dc.identifier.wos000454770900012
dc.identifier.doi10.1080/00365513.2018.1528504
dc.identifier.pmid30755099
dc.identifier.scopus2-s2.0-85059521799
dc.identifier.rcubconv_4286
dc.type.versionpublishedVersion


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