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dc.creatorRupar, Jelena
dc.creatorAleksić, Mara
dc.creatorNikolić, Katarina
dc.creatorPopović-Nikolić, Marija
dc.date.accessioned2019-09-02T12:05:57Z
dc.date.available2019-09-02T12:05:57Z
dc.date.issued2018
dc.identifier.issn0013-4686
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3145
dc.description.abstractThe electrochemical response of two biologically important benzopyrazine derivative, Quinoxaline and Brimonidine (5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxaline-6-amine) was studied at glassy carbon electrode. Investigations were performed in acetate buffer at pH 3.6 where both compounds undergo complex electrode process which begins with quasi reversible redox process at pyrazine ring forming di-hydro derivative, which is further irreversible oxidized to hydroxyl-derivative. Cyclic voltammetry at different scan rates was employed for the determination of heterogeneous electron transfer rate constant and diffusion coefficient of the compounds. The values of electron transfer rate constant at different temperatures were used for the evaluation of thermodynamic parameters like enthalpy, entropy and Gibbs free energy changes, as well as apparent energy of activation. Computational study has been performed in order to evaluate some useful quantum chemical parameters with the aim to confirm and explain the difference in experimentally obtained kinetic and thermodynamic parameters of the investigated QUI and BRIM redox process. Results were compared with studies of similar compounds and pointed out the observed similarities and differences.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceElectrochimica Acta
dc.subjectQuinoxaline and Brimonidineen
dc.subjectKinetic and thermodynamic parametersen
dc.subjectRedox processen
dc.subjectComputational chemistryen
dc.titleComparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox processen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Катарина; Поповић-Николић, Марија; Aлексић, Мара; Рупар, Јелена;
dc.citation.volume271
dc.citation.spage220
dc.citation.epage231
dc.citation.other271: 220-231
dc.citation.rankM21
dc.identifier.wos000430369800027
dc.identifier.doi10.1016/j.electacta.2018.03.114
dc.identifier.scopus2-s2.0-85044621370
dc.type.versionpublishedVersion


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