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dc.creatorRamsay, Rona R.
dc.creatorPopović-Nikolić, Marija
dc.creatorNikolić, Katarina
dc.creatorUliassi, Elisa
dc.creatorBolognesi, Maria Laura
dc.date.accessioned2019-09-02T12:06:06Z
dc.date.available2019-09-02T12:06:06Z
dc.date.issued2018
dc.identifier.issn2001-1326
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3148
dc.description.abstractDiseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.en
dc.publisherSpringeropen, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsopenAccess
dc.sourceClinical and Translational Medicine
dc.subjectMulti-target drugsen
dc.subjectNeurodegenerationen
dc.subjectCanceren
dc.subjectCheminformaticsen
dc.subjectVirtual screeningen
dc.subjectBiological assaysen
dc.titleA perspective on multi-target drug discovery and design for complex diseasesen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractРамсаy, Рона Р.; Улиасси, Елиса; Николић, Катарина; Бологнеси, Мариа Лаура; Поповић-Николић, Марија;
dc.citation.volume7
dc.citation.other7: -
dc.identifier.wos000423130500001
dc.identifier.doi10.1186/s40169-017-0181-2
dc.identifier.pmid29340951
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1731/3146.pdf
dc.identifier.rcubconv_4040
dc.type.versionpublishedVersion


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