Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia
Апстракт
Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron an...d vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.
Кључне речи:
Lactobacillus plantarum 299v / iron / development / anemia / stabilityИзвор:
Chemical & Pharmaceutical Bulletin, 2018, 66, 4, 347-352Издавач:
- Pharmaceutical Soc Japan, Tokyo
Институција/група
PharmacyTY - JOUR AU - Korcok, Davor Jovan AU - Trsić-Milanović, Nada AU - Ivanović, Nevena AU - Đorđević, Brižita PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3150 AB - Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells. PB - Pharmaceutical Soc Japan, Tokyo T2 - Chemical & Pharmaceutical Bulletin T1 - Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia VL - 66 IS - 4 SP - 347 EP - 352 UR - https://hdl.handle.net/21.15107/rcub_farfar_3150 ER -
@article{ author = "Korcok, Davor Jovan and Trsić-Milanović, Nada and Ivanović, Nevena and Đorđević, Brižita", year = "2018", abstract = "Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.", publisher = "Pharmaceutical Soc Japan, Tokyo", journal = "Chemical & Pharmaceutical Bulletin", title = "Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia", volume = "66", number = "4", pages = "347-352", url = "https://hdl.handle.net/21.15107/rcub_farfar_3150" }
Korcok, D. J., Trsić-Milanović, N., Ivanović, N.,& Đorđević, B.. (2018). Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia. in Chemical & Pharmaceutical Bulletin Pharmaceutical Soc Japan, Tokyo., 66(4), 347-352. https://hdl.handle.net/21.15107/rcub_farfar_3150
Korcok DJ, Trsić-Milanović N, Ivanović N, Đorđević B. Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia. in Chemical & Pharmaceutical Bulletin. 2018;66(4):347-352. https://hdl.handle.net/21.15107/rcub_farfar_3150 .
Korcok, Davor Jovan, Trsić-Milanović, Nada, Ivanović, Nevena, Đorđević, Brižita, "Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia" in Chemical & Pharmaceutical Bulletin, 66, no. 4 (2018):347-352, https://hdl.handle.net/21.15107/rcub_farfar_3150 .