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dc.creatorPantelić, Ivana
dc.creatorIlić, Tanja
dc.creatorMarković, Bojan
dc.creatorSavić, Sanela
dc.creatorLukić, Milica
dc.creatorSavić, Snežana
dc.date.accessioned2019-09-02T12:06:10Z
dc.date.available2019-09-02T12:06:10Z
dc.date.issued2018
dc.identifier.issn0367-598X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3151
dc.description.abstractAfter decades long absence of an official consensus on the most appropriate evaluation method for in vitro skin performance of topical semisolid drugs, United States Pharmacopoeia (USP 39) finally suggested three types of testing equipment; however, all these provide data on drug release using inert synthetic membranes. Considering the need for a readily available membrane that would be more structurally similar to human skin, this paper provides a detailed protocol of a method for drug permeation assessment that uses heat-separated porcine ear epidermis and modified Franz diffusion cells. Phases that were shown to be critical for variability of the results are identified (e.g., membrane preparation), and process parameters optimized. Applicability of the method was tested on four cream samples loaded with aceclofenac as a model drug. Sample compositions were designed in such a way to provide, large "variations (variation of the main stabilizer: natural-origin versus synthetic emulsifier) and relatively, minor" variations (co-solvent variation: none/isopropanol/glycerol). The developed protocol is a straightforward and reliable in vitro test for the evaluation of rate and extent of drug delivery into/through the skin. Moreover, this protocol may be routinely applied even in averagely equipped laboratories during formulation development or preliminary bioequivalence assessment of generic topical semisolids.en
dc.publisherSavez hemijskih inženjera, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.sourceHemijska industrija
dc.subjectdermal drug deliveryen
dc.subjectrate and extent of drug permeationen
dc.subjecthydrophilic creamsen
dc.subjectaceclofenacen
dc.titleA stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cellsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСавић, Санела; Савић, Снежана; Илић, Тања; Лукић, Милица; Марковић, Бојан; Пантелић, Ивана;
dc.citation.volume72
dc.citation.issue1
dc.citation.spage47
dc.citation.epage53
dc.citation.other72(1): 47-53
dc.citation.rankM23
dc.identifier.wos000429312400006
dc.identifier.doi10.2298/HEMIND170726019P
dc.identifier.scopus2-s2.0-85043756818
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1734/3149.pdf
dc.identifier.rcubconv_4099
dc.type.versionpublishedVersion


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