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dc.creatorBojanin, Dragana
dc.creatorMilenković, Tatjana
dc.creatorVekić, Jelena
dc.creatorVuković, Rade
dc.creatorZeljković, Aleksandra
dc.creatorJanac, Jelena
dc.creatorIvanišević, Jasmina
dc.creatorTodorović, Slađana
dc.creatorMazibrada, Ilijana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.date.accessioned2019-09-02T12:06:16Z
dc.date.available2019-09-02T12:06:16Z
dc.date.issued2018
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3153
dc.description.abstractObjective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P lt 0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P lt 0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P lt 0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P lt 0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P lt 0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectType 1 diabetes mellitusen
dc.subjectCeliac diseaseen
dc.subjectAutoimmune thyroiditisen
dc.subjectHDLen
dc.subjectLDLen
dc.subjectCardiovascular risken
dc.titleEffects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitusen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВуковић, Раде; Векић, Јелена; Тодоровић, Слађана; Мазибрада, Илијана; Спасојевић-Калимановска, Весна; Зељковић, Aлександра; Иванишевић, Јасмина; Бојанин, Драгана; Јанац, Јелена; Миленковић, Татјана;
dc.citation.volume54
dc.citation.spage11
dc.citation.epage17
dc.citation.other54: 11-17
dc.citation.rankM22
dc.identifier.wos000429426000002
dc.identifier.doi10.1016/j.clinbiochem.2018.01.026
dc.identifier.pmid29410325
dc.identifier.scopus2-s2.0-85044781789
dc.identifier.rcubconv_4100
dc.type.versionpublishedVersion


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