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Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus
dc.creator | Bojanin, Dragana | |
dc.creator | Milenković, Tatjana | |
dc.creator | Vekić, Jelena | |
dc.creator | Vuković, Rade | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Janać, Jelena | |
dc.creator | Ivanišević, Jasmina | |
dc.creator | Todorović, Slađana | |
dc.creator | Mazibrada, Ilijana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.date.accessioned | 2019-09-02T12:06:16Z | |
dc.date.available | 2019-09-02T12:06:16Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3153 | |
dc.description.abstract | Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P lt 0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P lt 0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P lt 0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P lt 0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P lt 0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Type 1 diabetes mellitus | en |
dc.subject | Celiac disease | en |
dc.subject | Autoimmune thyroiditis | en |
dc.subject | HDL | en |
dc.subject | LDL | en |
dc.subject | Cardiovascular risk | en |
dc.title | Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вуковић, Раде; Векић, Јелена; Тодоровић, Слађана; Мазибрада, Илијана; Спасојевић-Калимановска, Весна; Зељковић, Aлександра; Иванишевић, Јасмина; Бојанин, Драгана; Јанац, Јелена; Миленковић, Татјана; | |
dc.citation.volume | 54 | |
dc.citation.spage | 11 | |
dc.citation.epage | 17 | |
dc.citation.other | 54: 11-17 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000429426000002 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2018.01.026 | |
dc.identifier.pmid | 29410325 | |
dc.identifier.scopus | 2-s2.0-85044781789 | |
dc.type.version | publishedVersion |