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dc.creatorIlić-Stojanović, Snežana
dc.creatorNikolić, Vesna D.
dc.creatorKundaković, Tatjana
dc.creatorSavić, Ivan
dc.creatorSavić-Gajić, Ivana
dc.creatorJocić, Emilija
dc.creatorNikolić, Ljubiša
dc.date.accessioned2019-09-02T12:06:18Z
dc.date.available2019-09-02T12:06:18Z
dc.date.issued2018
dc.identifier.issn0091-4037
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3155
dc.description.abstractStimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]en
dc.publisherTaylor & Francis As, Oslo
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.subjectAlchemilla vulgaris Len
dc.subjectellagic aciden
dc.subjecthydrogelsen
dc.subjectN-isopropylacrylamideen
dc.subjectthermosensitive releaseen
dc.titleThermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extracten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКундаковић, Татјана; Николић, Весна Д.; Николић, Љубиша; Јоцић, Емилија; Савић-Гајић, Ивана; Илић-Стојановић, Снежана; Савић, Иван;
dc.citation.volume67
dc.citation.issue9
dc.citation.spage553
dc.citation.epage563
dc.citation.other67(9): 553-563
dc.citation.rankM22
dc.description.otherPeer-reviewed manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3421]
dc.identifier.wos000429604500003
dc.identifier.doi10.1080/00914037.2017.1354202
dc.identifier.scopus2-s2.0-85029429225
dc.identifier.rcubconv_4103
dc.type.versionpublishedVersion


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