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dc.creatorTubić, Biljana
dc.creatorVladimirov, Sandra
dc.creatorMarković, Bojan
dc.creatorSabo, Tibor
dc.date.accessioned2019-09-02T12:06:20Z
dc.date.available2019-09-02T12:06:20Z
dc.date.issued2018
dc.identifier.issn1318-0207
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3156
dc.description.abstractO,O'-diethyl-(S, S)-ethylenediamine-N, N'-di-2-(3-cyclohexyl) propanoate (DE-EDCP) is novel substance with cytotoxic activity in human leukemic cells. The aim of this study has been to predict in vivo bioavailability of the DE-EDCP and its potential metabolite (S, S)-ethylenediamine-N, N'-di-2-(3-cyclohexyl) propanoic acid (EDCP) by in vitro characterization which includes determination of lipophilicity and passive membrane permeability. There has also been evaluated inter-laboratory reproducibility of the bio-analytical method which was previously developed and validated for non-clinical study of the DE-EDCP and EDCP. Distribution coefficient n-octanol/water was 1.68 and 0.03, and apparent permeability coefficient was 4 x 10(-4) cm/s and 20 x 10(-4) cm/s, for the DE-EDCP and EDCP, respectively. Observed results have shown that the DE-EDCP is more lipophilic with better membrane retention, but the EDCP has better pass through the membrane. Also, there has been demonstrated a reproducibility and robustness of the proposed bio-analytical method.en
dc.publisherSlovensko Kemijsko Drustvo, Ljubljana
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsopenAccess
dc.sourceActa Chimica Slovenica
dc.subjectTransfer of the UHPLC-MS/MSen
dc.subjectcross validationen
dc.subject(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid estersen
dc.subjectmembrane permeabilityen
dc.subjectlipophilicityen
dc.titlePrediction of in vivo Bioavailibility by in vitro Characterization of Ethylenediamine Dipropanoic Acid Derivatives with Cytotoxic Activityen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТубић, Биљана; Марковић, Бојан; Сабо, Тибор; Владимиров, Сандра;
dc.citation.volume65
dc.citation.issue1
dc.citation.spage59
dc.citation.epage64
dc.citation.other65(1): 59-64
dc.citation.rankM23
dc.identifier.wos000428179900006
dc.identifier.doi10.17344/acsi.2017.3477
dc.identifier.pmid29562114
dc.identifier.scopus2-s2.0-85044361213
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1739/3154.pdf
dc.identifier.rcubconv_4084
dc.type.versionpublishedVersion


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