ФарФаР - Фармацеутски факултет, репозиторијум
Универзитет у Београду, Фармацеутски факултет
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

The influence of magnesium on the activity of some enzymes (AST, ALT, ALP) and lead content in some tissues

Нема приказа
Аутори
Todorović, T
Vujanović, Dragana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Many authors in different studies have reported the antagonism between Mg and Pb. Our previous results suggested that oral Mg treatment have better effect on investigation biochemical parameters (protoporphyrins, aminolevulinic acid - ALA and d-aminolevulinic dehydrataseALA-D) used in evaluating Pb intoxication, then CaNa(2)EDTA, chelation agens, currently used in therapy of Pb intoxication. The toxic effect of Pb induced considerably modifies the activity of many other enzymes. In this work we have examined the influence of Mg (as alternative therapy of Ph poisoning) on enzymes activity biochemical markers for general health conditions - aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in condition of lead intoxication. Many studies showed disturbances of activity ALT, AST and ALP The aim of this study was to confirm positive effects of Mg intake in condition of such intoxication at the level on activity of investigated enzymes. The exper...iment was performed on 45 male Wister rats, divided in three groups. I - control group; II - group treated daily for 30 days with 100 mg Pb, per kg body weight and next 60 without Pb treatment (spontaneous detoxication); III group - the same treatment as II group for the first 30 days, but next 60 days rats were treated orally with 40 mg Mg/kg body weight. Activity of AST and ALT was significant increased in condition of Pb poisoning, but ALP activity was significant reduced. Influence of excessive oral Mg treatment was positive: decrease of AST activity and ALT activity, which was probably in correlation with significant elimination of Ph from liver and increase of ALT enzyme activity at the normal level.

Извор:
Magnesium Research, 2002, 15, 3-4, 173-177
Издавач:
  • John Libbey & Co Ltd, London

ISSN: 0953-1424

PubMed: 12635869

WoS: 000181254500005

[ Google Scholar ]
11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/315
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумИнституцијеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB