Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type
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2018
Authors
Živković, IrenaPetrović, Raisa
Arsenović-Ranin, Nevena

Petrusić, Vladimir
Minić, Rajna

Bufan, Biljana

Popović, Olga
Leposavić, Gordana

Article (Published version)

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The study explored influence of biological sex on development of humoral immune response to seasonal trivalent whole inactivated virus (WIV) and split virus (SV) influenza vaccines in outbred Swiss mouse model. To this end, mice of both sexes were immunized with WIV (WIV mice) and SV vaccines (SV mice) and examined for specific antibody response. Irrespective of sex, total IgG and neutralizing antibody responses to distinct virus strains were weaker in SV than in WIV mice. In WIV mice of both sexes, irrespective of strain specificity, IgG isotype response was dominated by IgG2a antibodies, while in SV mice nearly equal representation of IgG2a and IgG1 antibodies was found. The analyses of sex differences showed higher titers of H1N1-specific and both H1N1- and H3N2-specific total IgG and neutralizing antibodies in female WIV and SV mice, respectively. Additionally, sexual dimorphism in IgG subclass profile depended on vaccine type. Specifically, compared with males, in females WIV shif...ted IgG2a/IgG1 antibody ratio towards IgG2a isotype on the account of weaker IgG1 response, whereas in SV mice, irrespective of virus strain, IgG2a and IgG1 isotypes were equally represented in both sexes. These findings indicate the vaccine type-dependent sex bias in antibody response to inactivated influenza vaccines.
Keywords:
Antibody response / Influenza virus strain / Sex differences / Split virus influenza vaccine / Whole virus influenza vaccineSource:
Biologicals, 2018, 52, 18-24Publisher:
- Academic Press Ltd- Elsevier Science Ltd, London
Funding / projects:
DOI: 10.1016/j.biologicals.2018.01.007
ISSN: 1045-1056
PubMed: 29426673
WoS: 000430880900003
Scopus: 2-s2.0-85044652872
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PharmacyTY - JOUR AU - Živković, Irena AU - Petrović, Raisa AU - Arsenović-Ranin, Nevena AU - Petrusić, Vladimir AU - Minić, Rajna AU - Bufan, Biljana AU - Popović, Olga AU - Leposavić, Gordana PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3160 AB - The study explored influence of biological sex on development of humoral immune response to seasonal trivalent whole inactivated virus (WIV) and split virus (SV) influenza vaccines in outbred Swiss mouse model. To this end, mice of both sexes were immunized with WIV (WIV mice) and SV vaccines (SV mice) and examined for specific antibody response. Irrespective of sex, total IgG and neutralizing antibody responses to distinct virus strains were weaker in SV than in WIV mice. In WIV mice of both sexes, irrespective of strain specificity, IgG isotype response was dominated by IgG2a antibodies, while in SV mice nearly equal representation of IgG2a and IgG1 antibodies was found. The analyses of sex differences showed higher titers of H1N1-specific and both H1N1- and H3N2-specific total IgG and neutralizing antibodies in female WIV and SV mice, respectively. Additionally, sexual dimorphism in IgG subclass profile depended on vaccine type. Specifically, compared with males, in females WIV shifted IgG2a/IgG1 antibody ratio towards IgG2a isotype on the account of weaker IgG1 response, whereas in SV mice, irrespective of virus strain, IgG2a and IgG1 isotypes were equally represented in both sexes. These findings indicate the vaccine type-dependent sex bias in antibody response to inactivated influenza vaccines. PB - Academic Press Ltd- Elsevier Science Ltd, London T2 - Biologicals T1 - Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type VL - 52 SP - 18 EP - 24 DO - 10.1016/j.biologicals.2018.01.007 ER -
@article{ author = "Živković, Irena and Petrović, Raisa and Arsenović-Ranin, Nevena and Petrusić, Vladimir and Minić, Rajna and Bufan, Biljana and Popović, Olga and Leposavić, Gordana", year = "2018", abstract = "The study explored influence of biological sex on development of humoral immune response to seasonal trivalent whole inactivated virus (WIV) and split virus (SV) influenza vaccines in outbred Swiss mouse model. To this end, mice of both sexes were immunized with WIV (WIV mice) and SV vaccines (SV mice) and examined for specific antibody response. Irrespective of sex, total IgG and neutralizing antibody responses to distinct virus strains were weaker in SV than in WIV mice. In WIV mice of both sexes, irrespective of strain specificity, IgG isotype response was dominated by IgG2a antibodies, while in SV mice nearly equal representation of IgG2a and IgG1 antibodies was found. The analyses of sex differences showed higher titers of H1N1-specific and both H1N1- and H3N2-specific total IgG and neutralizing antibodies in female WIV and SV mice, respectively. Additionally, sexual dimorphism in IgG subclass profile depended on vaccine type. Specifically, compared with males, in females WIV shifted IgG2a/IgG1 antibody ratio towards IgG2a isotype on the account of weaker IgG1 response, whereas in SV mice, irrespective of virus strain, IgG2a and IgG1 isotypes were equally represented in both sexes. These findings indicate the vaccine type-dependent sex bias in antibody response to inactivated influenza vaccines.", publisher = "Academic Press Ltd- Elsevier Science Ltd, London", journal = "Biologicals", title = "Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type", volume = "52", pages = "18-24", doi = "10.1016/j.biologicals.2018.01.007" }
Živković, I., Petrović, R., Arsenović-Ranin, N., Petrusić, V., Minić, R., Bufan, B., Popović, O.,& Leposavić, G.. (2018). Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type. in Biologicals Academic Press Ltd- Elsevier Science Ltd, London., 52, 18-24. https://doi.org/10.1016/j.biologicals.2018.01.007
Živković I, Petrović R, Arsenović-Ranin N, Petrusić V, Minić R, Bufan B, Popović O, Leposavić G. Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type. in Biologicals. 2018;52:18-24. doi:10.1016/j.biologicals.2018.01.007 .
Živković, Irena, Petrović, Raisa, Arsenović-Ranin, Nevena, Petrusić, Vladimir, Minić, Rajna, Bufan, Biljana, Popović, Olga, Leposavić, Gordana, "Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type" in Biologicals, 52 (2018):18-24, https://doi.org/10.1016/j.biologicals.2018.01.007 . .