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Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2

Authorized Users Only
2018
Authors
Klisić, Aleksandra
Kocić, Gordana
Kavarić, Nebojša
Jovanović, Milovan
Stanišić, Verica
Ninić, Ana
Article (Published version)
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Abstract
Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026)..., p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.

Keywords:
Albuminuria / Oxidative stress / Type 2 diabetes / Uric acid / Xanthine oxidase
Source:
Clinical and Experimental Medicine, 2018, 18, 2, 283-290
Publisher:
  • Springer-Verlag Italia Srl, Milan
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1007/s10238-017-0483-0

ISSN: 1591-8890

PubMed: 29214397

WoS: 000430980400015

Scopus: 2-s2.0-85037120612
[ Google Scholar ]
12
9
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
AB  - Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Clinical and Experimental Medicine
T1  - Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2
VL  - 18
IS  - 2
SP  - 283
EP  - 290
DO  - 10.1007/s10238-017-0483-0
ER  - 
@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Stanišić, Verica and Ninić, Ana",
year = "2018",
abstract = "Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Clinical and Experimental Medicine",
title = "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2",
volume = "18",
number = "2",
pages = "283-290",
doi = "10.1007/s10238-017-0483-0"
}
Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2018). Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine
Springer-Verlag Italia Srl, Milan., 18(2), 283-290.
https://doi.org/10.1007/s10238-017-0483-0
Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine. 2018;18(2):283-290.
doi:10.1007/s10238-017-0483-0 .
Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Stanišić, Verica, Ninić, Ana, "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2" in Clinical and Experimental Medicine, 18, no. 2 (2018):283-290,
https://doi.org/10.1007/s10238-017-0483-0 . .

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