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dc.creatorKlisić, Aleksandra
dc.creatorKocić, Gordana
dc.creatorKavarić, Nebojša
dc.creatorJovanović, Milovan
dc.creatorStanišić, Verica
dc.creatorNinić, Ana
dc.date.accessioned2019-09-02T12:06:28Z
dc.date.available2019-09-02T12:06:28Z
dc.date.issued2018
dc.identifier.issn1591-8890
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
dc.description.abstractXanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.en
dc.publisherSpringer-Verlag Italia Srl, Milan
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical and Experimental Medicine
dc.subjectAlbuminuriaen
dc.subjectOxidative stressen
dc.subjectType 2 diabetesen
dc.subjectUric aciden
dc.subjectXanthine oxidaseen
dc.titleXanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКаварић, Небојша; Јовановић, Милован; Коцић, Гордана; Клисић, Aлександра; Станишић, Верица; Нинић, Aна;
dc.citation.volume18
dc.citation.issue2
dc.citation.spage283
dc.citation.epage290
dc.citation.other18(2): 283-290
dc.citation.rankM22
dc.identifier.wos000430980400015
dc.identifier.doi10.1007/s10238-017-0483-0
dc.identifier.pmid29214397
dc.identifier.scopus2-s2.0-85037120612
dc.identifier.rcubconv_4111
dc.type.versionpublishedVersion


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