Show simple item record

dc.creatorDekanski, Dragana
dc.creatorPotparević, Biljana
dc.creatorBajić, Vladan
dc.creatorŽivković, Lada
dc.creatorTopalović, Dijana
dc.creatorSredojević, Dušan
dc.creatorLazić, Vesna
dc.creatorNedeljković, Jovan M.
dc.date.accessioned2019-09-02T12:06:34Z
dc.date.available2019-09-02T12:06:34Z
dc.date.issued2018
dc.identifier.issn0278-6915
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3165
dc.description.abstractThe acute toxicity of surface-modified TiO2 nanoparticles (NPs) with caffeic acid (CA) was compared with those of its separate constituents (free CA and bare TiO2 NPs) upon their oral administration in laboratory mice. Prior to in vivo experiments, the interfacial charge transfer (ICT) complex between surface Ti atoms and CA is thoroughly characterized. Composition and stability constants of ICT complex were determined using Job's method and Banesi-Hildebrand analysis, respectively. The experimental data were supported with quantum chemical calculations based on density functional theory (DFT). Acute toxicity signs, including biochemical alterations and extensive histopathological changes in the liver tissue of mice were detected 14 days after oral administration of bare TiO2 NPs. However, the clinical signs of toxicity, the fractional contribution of organs, biochemical parameters of liver and kidney function, and histopathological changes in liver upon treatment with surface-modified TiO2 NPs with CA were not observed. Also, the genotoxic potential of the ICT complex and its constituents were evaluated in leukocytes of whole blood cells in vivo by comet assay. Both, bare and surface-modified TiO2 NPs did not display DNA damaging effect in time frame of 24 h upon their oral administration in mice.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45020/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectTiO2 nanoparticlesen
dc.subjectCaffeic aciden
dc.subjectInterfacial charge transfer complexen
dc.subjectAcute oral toxicityen
dc.subjectComet assayen
dc.titleAcute toxicity study in mice of orally administrated TiO2 nanoparticles functionalized with caffeic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСредојевић, Душан; Лазић, Весна; Топаловић, Дијана; Живковић, Лада; Декански, Драгана; Бајић, Владан; Потпаревић, Биљана; Недељковић, Јован М.;
dc.citation.volume115
dc.citation.spage42
dc.citation.epage48
dc.citation.other115: 42-48
dc.citation.rankM21
dc.identifier.wos000432644400006
dc.identifier.doi10.1016/j.fct.2018.02.064
dc.identifier.pmid29510221
dc.identifier.scopus2-s2.0-85042915198
dc.identifier.rcubconv_4121
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record