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dc.creatorBojić, Suzana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorAleksić, Aleksandra
dc.creatorGacić, Jasna
dc.creatorMemon, Lidija
dc.creatorSimić-Ogrizović, Sanja
dc.date.accessioned2019-09-02T12:06:35Z
dc.date.available2019-09-02T12:06:35Z
dc.date.issued2018
dc.identifier.issn0278-0240
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3166
dc.description.abstractBackground. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceDisease Markers
dc.titleMatrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgeryen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractAлексић, Aлександра; Гацић, Јасна; Мемон, Лидија; Симић-Огризовић, Сања; Бојић, Сузана; Котур-Стевуљевић, Јелена;
dc.citation.rankM22
dc.identifier.wos000433386200001
dc.identifier.doi10.1155/2018/5064684
dc.identifier.pmid29861795
dc.identifier.scopus2-s2.0-85054934507
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1748/3164.pdf
dc.identifier.rcubconv_4124
dc.type.versionpublishedVersion


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