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Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
dc.creator | Bojić, Suzana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Aleksić, Aleksandra | |
dc.creator | Gacić, Jasna | |
dc.creator | Memon, Lidija | |
dc.creator | Simić-Ogrizović, Sanja | |
dc.date.accessioned | 2019-09-02T12:06:35Z | |
dc.date.available | 2019-09-02T12:06:35Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0278-0240 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3166 | |
dc.description.abstract | Background. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction. | en |
dc.publisher | Hindawi Ltd, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Disease Markers | |
dc.title | Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Aлексић, Aлександра; Гацић, Јасна; Мемон, Лидија; Симић-Огризовић, Сања; Бојић, Сузана; Котур-Стевуљевић, Јелена; | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000433386200001 | |
dc.identifier.doi | 10.1155/2018/5064684 | |
dc.identifier.pmid | 29861795 | |
dc.identifier.scopus | 2-s2.0-85054934507 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1748/3164.pdf | |
dc.type.version | publishedVersion |