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dc.creatorStojkovska, Jasmina
dc.creatorĐurđević, Željka
dc.creatorJančić, Ivan
dc.creatorBufan, Biljana
dc.creatorMilenković, Marina
dc.creatorJanković, Radmila
dc.creatorMišković-Stanković, Vesna
dc.creatorObradović, Bojana
dc.date.accessioned2019-09-02T12:06:41Z
dc.date.available2019-09-02T12:06:41Z
dc.date.issued2018
dc.identifier.issn0885-3282
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3169
dc.description.abstractIn the present study, possibilities for using novel nanocomposites based on alginate and silver nanoparticles for wound treatment were investigated in a second-degree thermal burn model in Wistar rats. Silver nanoparticles (AgNPs) were electrochemically synthesized in alginate solutions that were further utilized to obtain the Ag/alginate solution and microfibers for subsequent in vivo studies. Daily applications of the Ag/alginate colloid solution, containing AgNPs, alginate and ascorbic acid (G3), wet Ag/alginate microfibers containing AgNPs (G5) and dry Ag/alginate microfibers containing AgNPs (G6) were compared to treatments with a commercial cream containing silver sulfadiazine (G2) and a commercial Ca-alginate wound dressing containing silver ions (G4), as well as to the untreated controls (G1). Results of the in vivo study have shown faster healing in treated wounds, which completely healed on day 19 (G4, G5 and G6) and 21 (G2 and G3) after the thermal injury, while the period for complete reepitelization of untreated wounds (G1) was 25 days. The macroscopic analysis has shown that scabs fell off between day 10 and 12 after the thermal injury induction in treated groups, whereas between day 15 and 16 in the control group. These macroscopic findings were supported by the results of histopathological analyses, which have shown enhanced granulation and reepithelization, reduced inflammation and improved organization of the extracellular matrix in treated groups without adverse effects. Among the treated groups, dressings based on Ca-alginate (G4-G6) induced enhanced healing as compared to the other two groups (G2, G3), which could be attributed to additional stimuli of released Ca2+. The obtained results indicated potentials of novel nanocomposites based on alginate and AgNPs for therapeutic applications in wound treatments.en
dc.publisherSage Publications Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Biomaterials Applications
dc.subjectNanocompositesen
dc.subjectalginateen
dc.subjectsilver nanoparticlesen
dc.subjectAgen
dc.subjectalginate colloid solutionen
dc.subjectmicrofibersen
dc.subjectrat modelen
dc.subjectsecond degree thermal burnen
dc.titleComparative in vivo evaluation of novel formulations based on alginate and silver nanoparticles for wound treatmentsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈанчић, Иван; Миленковић, Марина; Мишковић-Станковић, Весна; Буфан, Биљана; Обрадовић, Бојана; Стојковска, Јасмина; Ђурђевић, Жељка; Јанковић, Радмила;
dc.citation.volume32
dc.citation.issue9
dc.citation.spage1197
dc.citation.epage1211
dc.citation.other32(9): 1197-1211
dc.citation.rankM22
dc.identifier.wos000429861500005
dc.identifier.doi10.1177/0885328218759564
dc.identifier.pmid29463162
dc.identifier.scopus2-s2.0-85042429643
dc.type.versionpublishedVersion


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