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dc.creatorAntonijević, Evica
dc.creatorKotur-Stevuljević, Jelena
dc.creatorMusilek, Kamil
dc.creatorKosvancova, Andrea
dc.creatorKuca, Kamil
dc.creatorĐukić-Ćosić, Danijela
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorAntonijević, Biljana
dc.date.accessioned2019-09-02T12:06:42Z
dc.date.available2019-09-02T12:06:42Z
dc.date.issued2018
dc.identifier.issn0340-5761
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3170
dc.description.abstractBeside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O-2 (center dot-)) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceArchives of Toxicology
dc.subjectPro-oxidantsen
dc.subjectAntioxidatsen
dc.subjectOxime K027en
dc.subjectOxime K203en
dc.subjectDichlorvosen
dc.subjectEfficacyen
dc.titleEffect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brainen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКуца, Камил; Aнтонијевић, Евица; Косванцова, Aндреа; Котур-Стевуљевић, Јелена; Спасојевић-Калимановска, Весна; Ђукић-Ћосић, Данијела; Мусилек, Камил; Aнтонијевић, Биљана;
dc.citation.volume92
dc.citation.issue2
dc.citation.spage745
dc.citation.epage757
dc.citation.other92(2): 745-757
dc.citation.rankaM21
dc.identifier.wos000425526000016
dc.identifier.doi10.1007/s00204-017-2101-z
dc.identifier.pmid29098328
dc.identifier.scopus2-s2.0-85032950416
dc.identifier.rcubconv_4059
dc.type.versionpublishedVersion


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