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dc.creatorDurić, Vedrana
dc.creatorBatinić, Bojan
dc.creatorPetrović, Jelena
dc.creatorStanić, Dušanka
dc.creatorBulat, Zorica
dc.creatorPešić, Vesna
dc.date.accessioned2019-09-02T12:06:43Z
dc.date.available2019-09-02T12:06:43Z
dc.date.issued2018
dc.identifier.issn0953-1424
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3172
dc.description.abstractAlthough a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.en
dc.publisherJohn Libbey Eurotext Ltd, Montrouge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceMagnesium Research
dc.subjectmagnesiumen
dc.subjectmemoryen
dc.subjectnovel object recognition testen
dc.subjectACTHen
dc.titleA single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДурић, Ведрана; Петровић, Јелена; Батинић, Бојан; Булат, Зорица; Станић, Душанка; Пешић, Весна;
dc.citation.volume31
dc.citation.issue1
dc.citation.spage24
dc.citation.epage32
dc.citation.other31(1): 24-32
dc.citation.rankM23
dc.identifier.wos000441152400003
dc.identifier.doi10.1684/mrh.2018.0435
dc.identifier.pmid29991463
dc.identifier.scopus2-s2.0-85051684199
dc.identifier.rcubconv_4189
dc.type.versionpublishedVersion


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