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A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats
dc.creator | Durić, Vedrana | |
dc.creator | Batinić, Bojan | |
dc.creator | Petrović, Jelena | |
dc.creator | Stanić, Dušanka | |
dc.creator | Bulat, Zorica | |
dc.creator | Pešić, Vesna | |
dc.date.accessioned | 2019-09-02T12:06:43Z | |
dc.date.available | 2019-09-02T12:06:43Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0953-1424 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3172 | |
dc.description.abstract | Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium. | en |
dc.publisher | John Libbey Eurotext Ltd, Montrouge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Magnesium Research | |
dc.subject | magnesium | en |
dc.subject | memory | en |
dc.subject | novel object recognition test | en |
dc.subject | ACTH | en |
dc.title | A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Дурић, Ведрана; Петровић, Јелена; Батинић, Бојан; Булат, Зорица; Станић, Душанка; Пешић, Весна; | |
dc.citation.volume | 31 | |
dc.citation.issue | 1 | |
dc.citation.spage | 24 | |
dc.citation.epage | 32 | |
dc.citation.other | 31(1): 24-32 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000441152400003 | |
dc.identifier.doi | 10.1684/mrh.2018.0435 | |
dc.identifier.pmid | 29991463 | |
dc.identifier.scopus | 2-s2.0-85051684199 | |
dc.type.version | publishedVersion |