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Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?

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2018
Authors
Kavarić, Nebojša
Klisić, Aleksandra
Ninić, Ana
Article (Published version)
Metadata
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Abstract
BackgroundVisceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). MethodsA total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. ResultsMultivariate logistic regression analysis showed that high-density lipoprotein cholesterol (HDL-c), (P lt .001), waist circumference (WC), (P=.027), age (P=.001), hypolipemic therapy (P=.024), and LAP (P=.005) were independent predictors of DM2 in adjusted models. In Receiver Operating... Characteristic curve analysis, used to discriminate subjects with DM2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC, HDL-c, triglycerides) and LAP (WC, triglycerides) indexes equations, respectively [Area under the curve (AUC)=0.819 and AUC=0.800, respectively], but not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves. ConclusionVisceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.

Keywords:
lipid accumulation product / obesity / type 2 diabetes mellitus / visceral adiposity index
Source:
Journal of Clinical Laboratory Analysis, 2018, 32, 3
Publisher:
  • Wiley, Hoboken
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1002/jcla.22283

ISSN: 0887-8013

PubMed: 28632304

WoS: 000427567700008

Scopus: 2-s2.0-85021276172
[ Google Scholar ]
18
15
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3175
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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