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dc.creatorMilovanović, Vesna
dc.creatorBuha, Aleksandra
dc.creatorMatović, Vesna
dc.creatorĆurčić, Marijana
dc.creatorVučinić, Slavica
dc.creatorNakano, Takeshi
dc.creatorAntonijević, Biljana
dc.date.accessioned2019-09-02T12:06:50Z
dc.date.available2019-09-02T12:06:50Z
dc.date.issued2018
dc.identifier.issn0944-1344
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3176
dc.description.abstractFully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceEnvironmental Science and Pollution Research
dc.subjectBDE-209en
dc.subjectNephrotoxicityen
dc.subjectOxidative stressen
dc.subjectCreatinineen
dc.subjectUreaen
dc.subjectRaten
dc.titleOxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНакано, Такесхи; Вучинић, Славица; Ћурчић, Маријана; Aнтонијевић, Биљана; Буха, Aлександра; Матовић, Весна; Миловановић, Весна;
dc.citation.volume25
dc.citation.issue8
dc.citation.spage7223
dc.citation.epage7230
dc.citation.other25(8): 7223-7230
dc.citation.rankM22
dc.identifier.wos000427398200014
dc.identifier.doi10.1007/s11356-015-5921-5
dc.identifier.pmid26676538
dc.identifier.scopus2-s2.0-84949975543
dc.identifier.rcubconv_4073
dc.type.versionpublishedVersion


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