The retention behavior of antihypertensive drugs of the type angiotensin-converting enzyme inhibitors on thin layers of aminoplast
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A rapid and simple method has been developed for chromatographic separation of the pharmacologically active components of some antibypertensive drugs. The active compounds - lisinopril, cilazapril, captopril, quinapril, and ramipril - were successfully separated on aminoplast layers with benzene-cyclohexane-methyl ethyl ketone, 15 + 10 + 15 (v/v), as mobile phase. The mechanism of retention and the correlation between lipophilicity and log P were both investigated.
Source:Journal of Planar Chromatography - Modern TLC, 2002, 15, 3, 210-213
- Research Inst Medicinal Plants, Budakalasz