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Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory

Authorized Users Only
2018
Authors
Drašković, Milica
Đuriš, Jelena
Ibrić, Svetlana
Parojčić, Jelena
Article (Published version)
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Abstract
In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and t...abletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.

Keywords:
Critical quality attributes / Functional property / Percolation threshold / Compressibility / Compactibility / Tabletability
Source:
Powder Technology, 2018, 326, 292-301
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)

DOI: 10.1016/j.powtec.2017.12.021

ISSN: 0032-5910

WoS: 000425077200034

Scopus: 2-s2.0-85038807236
[ Google Scholar ]
19
13
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3184
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Drašković, Milica
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3184
AB  - In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and tabletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.
PB  - Elsevier Science BV, Amsterdam
T2  - Powder Technology
T1  - Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory
VL  - 326
SP  - 292
EP  - 301
DO  - 10.1016/j.powtec.2017.12.021
ER  - 
@article{
author = "Drašković, Milica and Đuriš, Jelena and Ibrić, Svetlana and Parojčić, Jelena",
year = "2018",
abstract = "In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and tabletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Powder Technology",
title = "Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory",
volume = "326",
pages = "292-301",
doi = "10.1016/j.powtec.2017.12.021"
}
Drašković, M., Đuriš, J., Ibrić, S.,& Parojčić, J.. (2018). Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory. in Powder Technology
Elsevier Science BV, Amsterdam., 326, 292-301.
https://doi.org/10.1016/j.powtec.2017.12.021
Drašković M, Đuriš J, Ibrić S, Parojčić J. Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory. in Powder Technology. 2018;326:292-301.
doi:10.1016/j.powtec.2017.12.021 .
Drašković, Milica, Đuriš, Jelena, Ibrić, Svetlana, Parojčić, Jelena, "Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory" in Powder Technology, 326 (2018):292-301,
https://doi.org/10.1016/j.powtec.2017.12.021 . .

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