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dc.creatorDrašković, Milica
dc.creatorĐuriš, Jelena
dc.creatorIbrić, Svetlana
dc.creatorParojčić, Jelena
dc.date.accessioned2019-09-02T12:07:03Z
dc.date.available2019-09-02T12:07:03Z
dc.date.issued2018
dc.identifier.issn0032-5910
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3184
dc.description.abstractIn the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and tabletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourcePowder Technology
dc.subjectCritical quality attributesen
dc.subjectFunctional propertyen
dc.subjectPercolation thresholden
dc.subjectCompressibilityen
dc.subjectCompactibilityen
dc.subjectTabletabilityen
dc.titleFunctionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theoryen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПаројчић, Јелена; Ђуриш, Јелена; Драшковић, Милица; Ибрић, Светлана;
dc.citation.volume326
dc.citation.spage292
dc.citation.epage301
dc.citation.other326: 292-301
dc.citation.rankM21
dc.identifier.wos000425077200034
dc.identifier.doi10.1016/j.powtec.2017.12.021
dc.identifier.scopus2-s2.0-85038807236
dc.identifier.rcubconv_4051
dc.type.versionpublishedVersion


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