ФарФаР - Фармацеутски факултет, репозиторијум
Универзитет у Београду, Фармацеутски факултет
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед записа 
  •   ФарФаР
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед записа
  •   ФарФаР
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед записа
JavaScript is disabled for your browser. Some features of this site may not work without it.

Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

Само за регистроване кориснике
2018
Аутори
Velaga, Sitaram P.
Đuriš, Jelena
Cvijić, Sandra
Rozou, Stavroula
Russo, Paola
Colombo, Gaia
Rossi, Alessandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting in...terplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.

Кључне речи:
Pulmonary delivery / Dry powder inhalation / Solubility / Dissolution methods / Biopharmaceutical classification
Извор:
European Journal of Pharmaceutical Sciences, 2018, 113, 18-28
Издавач:
  • Elsevier Science BV, Amsterdam
Финансирање / пројекти:
  • EU COST Action MP1404

DOI: 10.1016/j.ejps.2017.09.002

ISSN: 0928-0987

PubMed: 28887232

WoS: 000424975800003

Scopus: 2-s2.0-85029717101
[ Google Scholar ]
42
31
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3187
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Pharmacy
TY  - JOUR
AU  - Velaga, Sitaram P.
AU  - Đuriš, Jelena
AU  - Cvijić, Sandra
AU  - Rozou, Stavroula
AU  - Russo, Paola
AU  - Colombo, Gaia
AU  - Rossi, Alessandra
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3187
AB  - In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
VL  - 113
SP  - 18
EP  - 28
DO  - 10.1016/j.ejps.2017.09.002
ER  - 
@article{
author = "Velaga, Sitaram P. and Đuriš, Jelena and Cvijić, Sandra and Rozou, Stavroula and Russo, Paola and Colombo, Gaia and Rossi, Alessandra",
year = "2018",
abstract = "In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products",
volume = "113",
pages = "18-28",
doi = "10.1016/j.ejps.2017.09.002"
}
Velaga, S. P., Đuriš, J., Cvijić, S., Rozou, S., Russo, P., Colombo, G.,& Rossi, A.. (2018). Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 113, 18-28.
https://doi.org/10.1016/j.ejps.2017.09.002
Velaga SP, Đuriš J, Cvijić S, Rozou S, Russo P, Colombo G, Rossi A. Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products. in European Journal of Pharmaceutical Sciences. 2018;113:18-28.
doi:10.1016/j.ejps.2017.09.002 .
Velaga, Sitaram P., Đuriš, Jelena, Cvijić, Sandra, Rozou, Stavroula, Russo, Paola, Colombo, Gaia, Rossi, Alessandra, "Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products" in European Journal of Pharmaceutical Sciences, 113 (2018):18-28,
https://doi.org/10.1016/j.ejps.2017.09.002 . .

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумГрупеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB