Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
Само за регистроване кориснике
2018
Аутори
Velaga, Sitaram P.Đuriš, Jelena

Cvijić, Sandra

Rozou, Stavroula
Russo, Paola

Colombo, Gaia
Rossi, Alessandra
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting in...terplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.
Кључне речи:
Pulmonary delivery / Dry powder inhalation / Solubility / Dissolution methods / Biopharmaceutical classificationИзвор:
European Journal of Pharmaceutical Sciences, 2018, 113, 18-28Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
- EU COST Action MP1404
DOI: 10.1016/j.ejps.2017.09.002
ISSN: 0928-0987
PubMed: 28887232
WoS: 000424975800003
Scopus: 2-s2.0-85029717101
Институција/група
PharmacyTY - JOUR AU - Velaga, Sitaram P. AU - Đuriš, Jelena AU - Cvijić, Sandra AU - Rozou, Stavroula AU - Russo, Paola AU - Colombo, Gaia AU - Rossi, Alessandra PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3187 AB - In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined. PB - Elsevier Science BV, Amsterdam T2 - European Journal of Pharmaceutical Sciences T1 - Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products VL - 113 SP - 18 EP - 28 DO - 10.1016/j.ejps.2017.09.002 ER -
@article{ author = "Velaga, Sitaram P. and Đuriš, Jelena and Cvijić, Sandra and Rozou, Stavroula and Russo, Paola and Colombo, Gaia and Rossi, Alessandra", year = "2018", abstract = "In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.", publisher = "Elsevier Science BV, Amsterdam", journal = "European Journal of Pharmaceutical Sciences", title = "Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products", volume = "113", pages = "18-28", doi = "10.1016/j.ejps.2017.09.002" }
Velaga, S. P., Đuriš, J., Cvijić, S., Rozou, S., Russo, P., Colombo, G.,& Rossi, A.. (2018). Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products. in European Journal of Pharmaceutical Sciences Elsevier Science BV, Amsterdam., 113, 18-28. https://doi.org/10.1016/j.ejps.2017.09.002
Velaga SP, Đuriš J, Cvijić S, Rozou S, Russo P, Colombo G, Rossi A. Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products. in European Journal of Pharmaceutical Sciences. 2018;113:18-28. doi:10.1016/j.ejps.2017.09.002 .
Velaga, Sitaram P., Đuriš, Jelena, Cvijić, Sandra, Rozou, Stavroula, Russo, Paola, Colombo, Gaia, Rossi, Alessandra, "Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products" in European Journal of Pharmaceutical Sciences, 113 (2018):18-28, https://doi.org/10.1016/j.ejps.2017.09.002 . .