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dc.creatorVelaga, Sitaram P.
dc.creatorĐuriš, Jelena
dc.creatorCvijić, Sandra
dc.creatorRozou, Stavroula
dc.creatorRusso, Paola
dc.creatorColombo, Gaia
dc.creatorRossi, Alessandra
dc.date.accessioned2019-09-02T12:07:05Z
dc.date.available2019-09-02T12:07:05Z
dc.date.issued2018
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3187
dc.description.abstractIn vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated. This review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhalers, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent biorelevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationEU COST Action MP1404
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectPulmonary deliveryen
dc.subjectDry powder inhalationen
dc.subjectSolubilityen
dc.subjectDissolution methodsen
dc.subjectBiopharmaceutical classificationen
dc.titleDry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug productsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂуриш, Јелена; Розоу, Ставроула; Велага, Ситарам П.; Цвијић, Сандра; Цоломбо, Гаиа; Росси, Aлессандра; Руссо, Паола;
dc.citation.volume113
dc.citation.spage18
dc.citation.epage28
dc.citation.other113: 18-28
dc.citation.rankM21
dc.identifier.wos000424975800003
dc.identifier.doi10.1016/j.ejps.2017.09.002
dc.identifier.pmid28887232
dc.identifier.scopus2-s2.0-85029717101
dc.identifier.rcubconv_4048
dc.type.versionpublishedVersion


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