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The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Cerne, Darko | |
dc.creator | Zupan, Janja | |
dc.creator | Marc, Janja | |
dc.creator | Vujić, Zorica | |
dc.creator | Crevar-Sakač, Milkica | |
dc.creator | Sopić, Miron | |
dc.creator | Munjas, Jelena | |
dc.creator | Radenković, Miroslav | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.date.accessioned | 2019-09-02T12:07:10Z | |
dc.date.available | 2019-09-02T12:07:10Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1388-0209 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3189 | |
dc.description.abstract | Context: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. Materials and methods: Eighteen male Wistar albino rats were divided into three groups (n=6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin. Results: Normalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049]. Conclusions: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Pharmaceutical Biology | |
dc.subject | Oxidative damage | en |
dc.subject | haemeoxygenase-1 | en |
dc.subject | monocyte chemoattractant protein-1 | en |
dc.subject | gene expression | en |
dc.title | The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Богавац-Станојевић, Наташа; Муњас, Јелена; Цревар-Сакач, Милкица; Марц, Јања; Церне, Дарко; Зупан, Јања; Сопић, Мирон; Јелић-Ивановић, Зорана; Вујић, Зорица; Раденковић, Мирослав; Котур-Стевуљевић, Јелена; | |
dc.citation.volume | 56 | |
dc.citation.issue | 1 | |
dc.citation.spage | 138 | |
dc.citation.epage | 144 | |
dc.citation.other | 56(1): 138-144 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000424493300001 | |
dc.identifier.doi | 10.1080/13880209.2018.1434549 | |
dc.identifier.pmid | 29409377 | |
dc.identifier.scopus | 2-s2.0-85046750511 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1768/3187.pdf | |
dc.type.version | publishedVersion |