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dc.creatorBogavac-Stanojević, Nataša
dc.creatorKotur-Stevuljević, Jelena
dc.creatorCerne, Darko
dc.creatorZupan, Janja
dc.creatorMarc, Janja
dc.creatorVujić, Zorica
dc.creatorCrevar-Sakač, Milkica
dc.creatorSopić, Miron
dc.creatorMunjas, Jelena
dc.creatorRadenković, Miroslav
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T12:07:10Z
dc.date.available2019-09-02T12:07:10Z
dc.date.issued2018
dc.identifier.issn1388-0209
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3189
dc.description.abstractContext: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. Materials and methods: Eighteen male Wistar albino rats were divided into three groups (n=6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin. Results: Normalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049]. Conclusions: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourcePharmaceutical Biology
dc.subjectOxidative damageen
dc.subjecthaemeoxygenase-1en
dc.subjectmonocyte chemoattractant protein-1en
dc.subjectgene expressionen
dc.titleThe role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic dieten
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractБогавац-Станојевић, Наташа; Муњас, Јелена; Цревар-Сакач, Милкица; Марц, Јања; Церне, Дарко; Зупан, Јања; Сопић, Мирон; Јелић-Ивановић, Зорана; Вујић, Зорица; Раденковић, Мирослав; Котур-Стевуљевић, Јелена;
dc.citation.volume56
dc.citation.issue1
dc.citation.spage138
dc.citation.epage144
dc.citation.other56(1): 138-144
dc.citation.rankM21
dc.identifier.wos000424493300001
dc.identifier.doi10.1080/13880209.2018.1434549
dc.identifier.pmid29409377
dc.identifier.scopus2-s2.0-85046750511
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1768/3187.pdf
dc.type.versionpublishedVersion


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