Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity
Article (Published version)
MetadataShow full item record
The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the thymus undergoes involution leading to the decline in efficacy of thymopoiesis. Noradrenaline from thymic nerve fibers and "(nor) adrenergic" cells is involved in the regulation of thymopoiesis. In rodents, noradrenaline concentration in thymus and adrenoceptor (AR) expression on thymic cells depend on sex and age. These differences are suggested to be implicated in the development of sexual diergism and the age-related decline in thymopoiesis. The programming of both thymic sexual differentiation and its involution occurs during the critical early perinatal period and may be reprogrammed during peripubertal development. The thymic (re) programming is critically dependent on circulating levels of gonadal steroids. Although the underlying molecular mechanisms have not yet ...been elucidated fully, it is assumed that the gonadal steroid action during the critical perinatal/peripubertal developmental periods leads to long-lasting changes in the efficacy of thymopoiesis partly through (re) programming of "(nor) adrenergic" cell networks and AR expression on thymic cells.
Keywords:thymic noradrenergic innervation / noradrenaline-synthesizing thymic cells / adrenoceptors / sex steroids / thymic involution / thymic programming/reprogramming
Source:Frontiers in Endocrinology, 2018, 9
- Frontiers Media Sa, Lausanne
Showing items related by title, author, creator and subject.
Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation Nacka-Aleksić, Mirjana; Pilipović, Ivan; Kotur-Stevuljević, Jelena; Petrović, Raisa; Sopta, Jelena; Leposavić, Gordana (Springer, New York, 2019)
Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids Pilipović, Ivan; Radojević, Katarina; Perišić, M.; Kosec, Duško; Nacka-Aleksić, Mirjana; Đikić, Jasmina; Leposavić, Gordana (Wiley-Blackwell, Hoboken, 2012)
Thymocyte apoptosis and proliferation modeling during rat thymic involution is influenced by ovarian hormones in a thymocyte subset-specific manner / Hormoni ovarijuma imaju različit uticaj na modelovanje apoptoze i proliferacije unutar različitih subpopulacija timocita tokom involucije timusa Arsenović-Ranin, Nevena; Nacka-Aleksić, Mirjana; Đikić, Jasmina; Perišić, Milica; Kosec, Duško; Pilipović, Ivan; Stojić-Vukanić, Zorica; Leposavić, Gordana (Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2013)