Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity
Апстракт
The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the thymus undergoes involution leading to the decline in efficacy of thymopoiesis. Noradrenaline from thymic nerve fibers and "(nor) adrenergic" cells is involved in the regulation of thymopoiesis. In rodents, noradrenaline concentration in thymus and adrenoceptor (AR) expression on thymic cells depend on sex and age. These differences are suggested to be implicated in the development of sexual diergism and the age-related decline in thymopoiesis. The programming of both thymic sexual differentiation and its involution occurs during the critical early perinatal period and may be reprogrammed during peripubertal development. The thymic (re) programming is critically dependent on circulating levels of gonadal steroids. Although the underlying molecular mechanisms have not yet ...been elucidated fully, it is assumed that the gonadal steroid action during the critical perinatal/peripubertal developmental periods leads to long-lasting changes in the efficacy of thymopoiesis partly through (re) programming of "(nor) adrenergic" cell networks and AR expression on thymic cells.
Кључне речи:
thymic noradrenergic innervation / noradrenaline-synthesizing thymic cells / adrenoceptors / sex steroids / thymic involution / thymic programming/reprogrammingИзвор:
Frontiers in Endocrinology, 2018, 9Издавач:
- Frontiers Media Sa, Lausanne
Финансирање / пројекти:
- Пластичност имунског система током старења: имуномодулаторни потенцијал естрогена (RS-MESTD-Basic Research (BR or ON)-175050)
DOI: 10.3389/fendo.2018.00013
ISSN: 1664-2392
PubMed: 29441042
WoS: 000423539400001
Scopus: 2-s2.0-85041624756
Институција/група
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Pilipović, Ivan PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3193 AB - The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the thymus undergoes involution leading to the decline in efficacy of thymopoiesis. Noradrenaline from thymic nerve fibers and "(nor) adrenergic" cells is involved in the regulation of thymopoiesis. In rodents, noradrenaline concentration in thymus and adrenoceptor (AR) expression on thymic cells depend on sex and age. These differences are suggested to be implicated in the development of sexual diergism and the age-related decline in thymopoiesis. The programming of both thymic sexual differentiation and its involution occurs during the critical early perinatal period and may be reprogrammed during peripubertal development. The thymic (re) programming is critically dependent on circulating levels of gonadal steroids. Although the underlying molecular mechanisms have not yet been elucidated fully, it is assumed that the gonadal steroid action during the critical perinatal/peripubertal developmental periods leads to long-lasting changes in the efficacy of thymopoiesis partly through (re) programming of "(nor) adrenergic" cell networks and AR expression on thymic cells. PB - Frontiers Media Sa, Lausanne T2 - Frontiers in Endocrinology T1 - Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity VL - 9 DO - 10.3389/fendo.2018.00013 ER -
@article{ author = "Leposavić, Gordana and Pilipović, Ivan", year = "2018", abstract = "The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the thymus undergoes involution leading to the decline in efficacy of thymopoiesis. Noradrenaline from thymic nerve fibers and "(nor) adrenergic" cells is involved in the regulation of thymopoiesis. In rodents, noradrenaline concentration in thymus and adrenoceptor (AR) expression on thymic cells depend on sex and age. These differences are suggested to be implicated in the development of sexual diergism and the age-related decline in thymopoiesis. The programming of both thymic sexual differentiation and its involution occurs during the critical early perinatal period and may be reprogrammed during peripubertal development. The thymic (re) programming is critically dependent on circulating levels of gonadal steroids. Although the underlying molecular mechanisms have not yet been elucidated fully, it is assumed that the gonadal steroid action during the critical perinatal/peripubertal developmental periods leads to long-lasting changes in the efficacy of thymopoiesis partly through (re) programming of "(nor) adrenergic" cell networks and AR expression on thymic cells.", publisher = "Frontiers Media Sa, Lausanne", journal = "Frontiers in Endocrinology", title = "Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity", volume = "9", doi = "10.3389/fendo.2018.00013" }
Leposavić, G.,& Pilipović, I.. (2018). Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity. in Frontiers in Endocrinology Frontiers Media Sa, Lausanne., 9. https://doi.org/10.3389/fendo.2018.00013
Leposavić G, Pilipović I. Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity. in Frontiers in Endocrinology. 2018;9. doi:10.3389/fendo.2018.00013 .
Leposavić, Gordana, Pilipović, Ivan, "Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity" in Frontiers in Endocrinology, 9 (2018), https://doi.org/10.3389/fendo.2018.00013 . .
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