A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.
Samo za registrovane korisnike
2018
Autori
Cvetanović, AleksandraZekovic, Zoran
Svarc-Gajic, Jaroslava
Ražić, Slavica
Damjanović, Ana B.
Zengin, Gokhan
Delerue-Matos, Cristina
Moreira, Manuela
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
BACKGROUND: To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSIONR: esults obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against alpha-amylase, alpha-glucosidase and tyrosinase, and the results showed the anti-diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A-549; LS...-174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58-8.10 mu g mL(-1). Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION: The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto-pharmaceuticals and functional food ingredients. (C) 2017 Society of Chemical Industry.
Ključne reči:
extraction / pharmaceuticals / supercritical fluids / subcritical water extraction / plantIzvor:
Journal of Chemical Technology and Biotechnology, 2018, 93, 4, 1097-1104Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Republic of Serbia / Portuguese Republic 451-03-01765/2014-09/28
- Ministerio da Ciencia, Tecnologia e Ensino Superior
- FCT/MEC
DOI: 10.1002/jctb.5468
ISSN: 0268-2575
WoS: 000426859900018
Scopus: 2-s2.0-85043326490
Institucija/grupa
PharmacyTY - JOUR AU - Cvetanović, Aleksandra AU - Zekovic, Zoran AU - Svarc-Gajic, Jaroslava AU - Ražić, Slavica AU - Damjanović, Ana B. AU - Zengin, Gokhan AU - Delerue-Matos, Cristina AU - Moreira, Manuela PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3194 AB - BACKGROUND: To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSIONR: esults obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against alpha-amylase, alpha-glucosidase and tyrosinase, and the results showed the anti-diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A-549; LS-174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58-8.10 mu g mL(-1). Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION: The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto-pharmaceuticals and functional food ingredients. (C) 2017 Society of Chemical Industry. PB - Wiley, Hoboken T2 - Journal of Chemical Technology and Biotechnology T1 - A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L. VL - 93 IS - 4 SP - 1097 EP - 1104 DO - 10.1002/jctb.5468 ER -
@article{ author = "Cvetanović, Aleksandra and Zekovic, Zoran and Svarc-Gajic, Jaroslava and Ražić, Slavica and Damjanović, Ana B. and Zengin, Gokhan and Delerue-Matos, Cristina and Moreira, Manuela", year = "2018", abstract = "BACKGROUND: To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSIONR: esults obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against alpha-amylase, alpha-glucosidase and tyrosinase, and the results showed the anti-diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A-549; LS-174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58-8.10 mu g mL(-1). Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION: The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto-pharmaceuticals and functional food ingredients. (C) 2017 Society of Chemical Industry.", publisher = "Wiley, Hoboken", journal = "Journal of Chemical Technology and Biotechnology", title = "A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.", volume = "93", number = "4", pages = "1097-1104", doi = "10.1002/jctb.5468" }
Cvetanović, A., Zekovic, Z., Svarc-Gajic, J., Ražić, S., Damjanović, A. B., Zengin, G., Delerue-Matos, C.,& Moreira, M.. (2018). A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.. in Journal of Chemical Technology and Biotechnology Wiley, Hoboken., 93(4), 1097-1104. https://doi.org/10.1002/jctb.5468
Cvetanović A, Zekovic Z, Svarc-Gajic J, Ražić S, Damjanović AB, Zengin G, Delerue-Matos C, Moreira M. A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.. in Journal of Chemical Technology and Biotechnology. 2018;93(4):1097-1104. doi:10.1002/jctb.5468 .
Cvetanović, Aleksandra, Zekovic, Zoran, Svarc-Gajic, Jaroslava, Ražić, Slavica, Damjanović, Ana B., Zengin, Gokhan, Delerue-Matos, Cristina, Moreira, Manuela, "A new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L." in Journal of Chemical Technology and Biotechnology, 93, no. 4 (2018):1097-1104, https://doi.org/10.1002/jctb.5468 . .