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dc.creatorCvetanović, Aleksandra
dc.creatorZekovic, Zoran
dc.creatorSvarc-Gajic, Jaroslava
dc.creatorRažić, Slavica
dc.creatorDamjanović, Ana B.
dc.creatorZengin, Gokhan
dc.creatorDelerue-Matos, Cristina
dc.creatorMoreira, Manuela
dc.date.accessioned2019-09-02T12:07:18Z
dc.date.available2019-09-02T12:07:18Z
dc.date.issued2018
dc.identifier.issn0268-2575
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3194
dc.description.abstractBACKGROUND: To obtain bioactive fractions from plant material subcritical water is notably advantageous in comparison to any other technique. Excellent solvating properties and selectivity combined with finely tuned reactivity of subcritical water enable exploitation of the potential of plants. Herein subcritical water extraction was used for recovery of bioactive compounds from leaves, roots and fruits of Sambucus ebulus L. Extracts obtained were characterized in terms of biological and chemical fingerprints. RESULTS AND DISCUSSIONR: esults obtained by using several antioxidant assays that focused on different mechanisms showed that subcritical water extracts of Sambucus ebulus were powerful antioxidants. Enzyme inhibitory effects were tested against alpha-amylase, alpha-glucosidase and tyrosinase, and the results showed the anti-diabetic potential of the extracts as well as its possible use with skin disorders. Antiproliferative properties were detected on three cell lines (A-549; LS-174 T; HeLa) and showed prominent cytotoxicity against all tumor cell lines. Inhibitory concentrations obtained were in the range 0.58-8.10 mu g mL(-1). Generally, the SCW extracts from leaves exhibited stronger biological activities with higher levels of phenolic compounds compared with the roots and fruits of Sambucus ebulus. Gallic acid, catechin and caffeic acid were identified as major components in these extracts and these components seem to relate with observed biological activity. CONCLUSION: The results obtained suggest that Sambucus ebulus has great potential for preparing new phyto-pharmaceuticals and functional food ingredients. (C) 2017 Society of Chemical Industry.en
dc.publisherWiley, Hoboken
dc.relationRepublic of Serbia / Portuguese Republic 451-03-01765/2014-09/28
dc.relationMinisterio da Ciencia, Tecnologia e Ensino Superior
dc.relationFCT/MEC
dc.rightsrestrictedAccess
dc.sourceJournal of Chemical Technology and Biotechnology
dc.subjectextractionen
dc.subjectpharmaceuticalsen
dc.subjectsupercritical fluidsen
dc.subjectsubcritical water extractionen
dc.subjectplanten
dc.titleA new source for developing multi-functional products: biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗенгин, Гокхан; Сварц-Гајиц, Јарослава; Дамјановић, Aна Б.; Ражић, Славица; Цветановић, Aлександра; Зековиц, Зоран; Делеруе-Матос, Цристина; Мореира, Мануела;
dc.citation.volume93
dc.citation.issue4
dc.citation.spage1097
dc.citation.epage1104
dc.citation.other93(4): 1097-1104
dc.citation.rankM22
dc.identifier.wos000426859900018
dc.identifier.doi10.1002/jctb.5468
dc.identifier.scopus2-s2.0-85043326490
dc.identifier.rcubconv_4065
dc.type.versionpublishedVersion


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