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dc.creatorVučinić, Slavica
dc.creatorKilibarda, Vesna
dc.creatorĐorđević, Snežana
dc.creatorĐorđević, Dragana
dc.creatorPerković-Vukcević, Nataša
dc.creatorVuković-Ercegović, Gordana
dc.creatorAntonijević, Biljana
dc.creatorĆurčić, Marijana
dc.creatorAntonijević, Evica
dc.creatorBrajković, Gordana
dc.date.accessioned2019-09-02T12:07:20Z
dc.date.available2019-09-02T12:07:20Z
dc.date.issued2018
dc.identifier.issn0004-1254
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3196
dc.description.abstractA rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.en
dc.publisherInst Medical Research & Occupational Health, Zagreb
dc.rightsopenAccess
dc.sourceArhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
dc.subjectchromatographyen
dc.subjectearly warning systemen
dc.subjectherbal incenseen
dc.subjectnew psychoactive substancesen
dc.subjectrainbow specialen
dc.subjectspectrometryen
dc.titleClinical and analytical experience of the National Poison Control Centre with synthetic cannabinoidsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнтонијевић, Биљана; Вуковић-Ерцеговић, Гордана; Перковић-Вукцевић, Наташа; Брајковић, Гордана; Ћурчић, Маријана; Ђорђевић, Драгана; Ђорђевић, Снежана; Вучинић, Славица; Килибарда, Весна; Aнтонијевић, Евица;
dc.citation.volume69
dc.citation.issue2
dc.citation.spage178
dc.citation.epage185
dc.citation.other69(2): 178-185
dc.citation.rankM23
dc.identifier.wos000438316900012
dc.identifier.doi10.2478/aiht-2018-69-3096
dc.identifier.pmid29990297
dc.identifier.scopus2-s2.0-85058349161
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1776/3194.pdf
dc.identifier.rcubconv_4153
dc.type.versionpublishedVersion


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