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dc.creatorMichalickova, Danica
dc.creatorKotur-Stevuljević, Jelena
dc.creatorMiljković, Milica
dc.creatorDikić, Nenad
dc.creatorKostić-Vučićević, Marija
dc.creatorAnđelković, Marija
dc.creatorKoricanac, Vladimir
dc.creatorĐorđević, Brižita
dc.date.accessioned2019-09-02T12:07:26Z
dc.date.available2019-09-02T12:07:26Z
dc.date.issued2018
dc.identifier.issn1640-5544
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3201
dc.description.abstractA randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti (R) L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti (R) L10. Before and after the supplementation serum samples were collected. Markers of oxidative stress and anti-oxidative defense: superoxide dismutase (SOD), paraoxonase (PON), advanced oxidation protein products (AOPP), malondialdehyde (MDA), total antioxidant status, total oxidant status, prooxidant-antioxidant balance, oxidative stress index, bilirubin, uric acid and albumin were determined in serum. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant interaction effect for MDA (p = 0.039), with a decrease in MDA in the probiotic group only (p = 0.049). There was a significant interaction effect for AOPP (p = 0.037), with a significant decrease in the probiotic group (p = 0.045). Interaction effect for SOD was approaching to formal significance (p = 0.108) and the post-hoc test showed a significant decrease in the probiotic group (p = 0.041) only. A significant correlation between AOPP and SOD (p = 0.012, r = -0.40) was found in the probiotic group at the end of the study. PON1 activity was decreased in both the probiotic (p = 0.032) and placebo group (p = 0.035). No significant changes in the remainder of the evaluated parameters were noted. In conclusion, probiotic strain Lafti (R) L10 exerts certain antioxidant potential, but further research is needed.en
dc.publisherDe Gruyter Poland Sp Zoo, Warsaw
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.sourceJournal of Human Kinetics
dc.subjectexerciseen
dc.subjectLactobacillusen
dc.subjectantioxidantsen
dc.subjectendurance athletesen
dc.titleEffects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant-Antioxidant Balance in Elite Athletes: A Double-Blind Randomized Placebo-Controlled Studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнђелковић, Марија; Котур-Стевуљевић, Јелена; Миљковић, Милица; Дикић, Ненад; Мицхалицкова, Даница; Корицанац, Владимир; Костић-Вучићевић, Марија; Ђорђевић, Брижита;
dc.citation.volume64
dc.citation.issue1
dc.citation.spage111
dc.citation.epage122
dc.citation.other64(1): 111-122
dc.citation.rankM23
dc.identifier.wos000447662500011
dc.identifier.doi10.1515/hukin-2017-0203
dc.identifier.pmid30429904
dc.identifier.scopus2-s2.0-85055628975
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1781/3199.pdf
dc.identifier.rcubconv_4159
dc.type.versionpublishedVersion


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