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Association between oxidative stress and melanoma progression

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2018
3204.pdf (227.5Kb)
Authors
Pantić Biševac, Jelena
Đukić, Mirjana
Stanojević, Ivan
Stevanović, Ivana
Mijušković, Željko
Đurić, Ana
Gobeljić, Borko
Banović, Tatjana
Vojvodić, Danilo
Article (Published version)
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Abstract
Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondi...aldehyde highest value was in stage IV. The activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV. Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level.

Keywords:
antioxidants / free radicals / melanoma / oxidative stress
Source:
Journal of Medical Biochemistry, 2018, 37, 1, 12-20
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita

DOI: 10.1515/jomb-2017-0040

ISSN: 1452-8258

PubMed: 30581337

WoS: 000417194100003

Scopus: 2-s2.0-85037829041
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3206
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Pharmacy

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