Association between oxidative stress and melanoma progression

2018
Authors
Pantić Biševac, JelenaĐukić, Mirjana

Stanojević, Ivan
Stevanović, Ivana
Mijušković, Željko
Đurić, Ana

Gobeljić, Borko

Banović, Tatjana
Vojvodić, Danilo

Article (Published version)

Metadata
Show full item recordAbstract
Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondi...aldehyde highest value was in stage IV. The activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV. Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level.
Keywords:
antioxidants / free radicals / melanoma / oxidative stressSource:
Journal of Medical Biochemistry, 2018, 37, 1, 12-20Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
DOI: 10.1515/jomb-2017-0040
ISSN: 1452-8258
PubMed: 30581337
WoS: 000417194100003
Scopus: 2-s2.0-85037829041
Collections
Institution/Community
PharmacyTY - JOUR AU - Pantić Biševac, Jelena AU - Đukić, Mirjana AU - Stanojević, Ivan AU - Stevanović, Ivana AU - Mijušković, Željko AU - Đurić, Ana AU - Gobeljić, Borko AU - Banović, Tatjana AU - Vojvodić, Danilo PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3206 AB - Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondialdehyde highest value was in stage IV. The activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV. Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Association between oxidative stress and melanoma progression VL - 37 IS - 1 SP - 12 EP - 20 DO - 10.1515/jomb-2017-0040 ER -
@article{ author = "Pantić Biševac, Jelena and Đukić, Mirjana and Stanojević, Ivan and Stevanović, Ivana and Mijušković, Željko and Đurić, Ana and Gobeljić, Borko and Banović, Tatjana and Vojvodić, Danilo", year = "2018", abstract = "Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondialdehyde highest value was in stage IV. The activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV. Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Association between oxidative stress and melanoma progression", volume = "37", number = "1", pages = "12-20", doi = "10.1515/jomb-2017-0040" }
Pantić Biševac, J., Đukić, M., Stanojević, I., Stevanović, I., Mijušković, Ž., Đurić, A., Gobeljić, B., Banović, T.,& Vojvodić, D.. (2018). Association between oxidative stress and melanoma progression. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 37(1), 12-20. https://doi.org/10.1515/jomb-2017-0040
Pantić Biševac J, Đukić M, Stanojević I, Stevanović I, Mijušković Ž, Đurić A, Gobeljić B, Banović T, Vojvodić D. Association between oxidative stress and melanoma progression. in Journal of Medical Biochemistry. 2018;37(1):12-20. doi:10.1515/jomb-2017-0040 .
Pantić Biševac, Jelena, Đukić, Mirjana, Stanojević, Ivan, Stevanović, Ivana, Mijušković, Željko, Đurić, Ana, Gobeljić, Borko, Banović, Tatjana, Vojvodić, Danilo, "Association between oxidative stress and melanoma progression" in Journal of Medical Biochemistry, 37, no. 1 (2018):12-20, https://doi.org/10.1515/jomb-2017-0040 . .