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dc.creatorPantić Biševac, Jelena
dc.creatorĐukić, Mirjana
dc.creatorStanojević, Ivan
dc.creatorStevanović, Ivana
dc.creatorMijušković, Željko
dc.creatorĐurić, Ana
dc.creatorGobeljić, Borko
dc.creatorBanović, Tatjana
dc.creatorVojvodić, Danilo
dc.date.accessioned2019-09-02T12:07:34Z
dc.date.available2019-09-02T12:07:34Z
dc.date.issued2018
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3206
dc.description.abstractBackground: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondialdehyde highest value was in stage IV. The activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV. Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectantioxidantsen
dc.subjectfree radicalsen
dc.subjectmelanomaen
dc.subjectoxidative stressen
dc.titleAssociation between oxidative stress and melanoma progressionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМијушковић, Жељко; Стевановић, Ивана; Гобељић, Борко; Ђукић, Мирјана; Станојевић, Иван; Бановић, Татјана; Ђурић, Aна; Бисевац, Јелена Пантиц; Војводић, Данило;
dc.citation.volume37
dc.citation.issue1
dc.citation.spage12
dc.citation.epage20
dc.citation.other37(1): 12-20
dc.citation.rankM23
dc.identifier.wos000417194100003
dc.identifier.doi10.1515/jomb-2017-0040
dc.identifier.pmid30581337
dc.identifier.scopus2-s2.0-85037829041
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1788/3204.pdf
dc.identifier.rcubconv_4012
dc.type.versionpublishedVersion


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