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Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives
dc.creator | Dobričić, Vladimir | |
dc.creator | Stanišić, Aleksa | |
dc.creator | Vladimirov, Sote | |
dc.creator | Čudina, Olivera | |
dc.date.accessioned | 2019-09-02T12:07:39Z | |
dc.date.available | 2019-09-02T12:07:39Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0933-4173 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3209 | |
dc.description.abstract | Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underlined. | en |
dc.publisher | Akademiai Kiado Zrt, Budapest | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Planar Chromatography - Modern TLC | |
dc.subject | Reversed-phased thin-layer chromatography | en |
dc.subject | 17 beta-Carboxamide glucocorticoid derivatives | en |
dc.subject | log Po/w | en |
dc.subject | Simple linear regression | en |
dc.title | Development of a Reversed-Phased Thin-Layer Chromatography Method for the Lipophilicity Prediction of 17β-Carboxamide Glucocorticoid Derivatives | |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Чудина, Оливера; Станисић, Aлекса; Добричић, Владимир; Владимиров, Соте; | |
dc.citation.volume | 31 | |
dc.citation.issue | 3 | |
dc.citation.spage | 250 | |
dc.citation.epage | 256 | |
dc.citation.other | 31(3): 250-256 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000439814400012 | |
dc.identifier.doi | 10.1556/1006.2018.31.3.11 | |
dc.identifier.scopus | 2-s2.0-85048951338 | |
dc.type.version | publishedVersion |