Приказ основних података о документу

dc.creatorFraneta, JT
dc.creatorAgbaba, Danica
dc.creatorErić, Slavica
dc.creatorPavkov, S
dc.creatorAleksić, Mirjana
dc.creatorVladimirov, S
dc.date.accessioned2019-09-02T10:54:04Z
dc.date.available2019-09-02T10:54:04Z
dc.date.issued2002
dc.identifier.issn0014-827X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/320
dc.description.abstractThis paper present a HPLC method for simultaneous determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets, using chromatographic system consisting a Bio Rad 18 01 solvent pump, Rheodine 71 25 injector and Bio Rad 18 01 UV-Vis Detector. Separation was achieved using Bio SiL HL C 18, 5 mum, 250 x 4.6 mm column. Mixture of acetonitrile-water (25:75 v/v) adjusted to pH 2.5 with phosphoric acid was used as a mobile phase at a flow rate of 2.0 ml(-1) min UV detection was at 207 nm range 0.01 AUFS. Under the same conditions it was possible to determine the level of salicylic acid. The chromatographic parameters such as retention times, capacity factor, peak asymmetry, selectivity factor and resolution factor was determined. The validation parameters: linearity (r > 0.998), intra-day precision (RSD: 0.36-1.89%) and inter-day precision (RSD: 0.58-2.18%), sensitivity (LOD: 9 x 10(-5)-1.7 x 10(-4) mg ml(-1) and LOQ: 2.5 x 10(-4)-5.6 x 10(-4) mg ml(-1)), accuracy (recoveries: 98.35-99.14%) and reproducibility (recovery values: 98.74-102.08% for acetylsalicylic acid, 99.93-102.11% for paracetamol, 98.25-102.12% for caffeine and 98.15-102.3% for phenobarbital) (RSD: 1.21-1.85%) were found to be satisfactory. The proposed HPLC method has been applied for the determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in Malophenum tablets. The obtained RSD values were within 0.99-1.21%. The developed method is rapid and sensitive and therefore suitable for routine control of these drugs in dosage form.en
dc.publisherElsevier Science Sa, Lausanne
dc.rightsrestrictedAccess
dc.sourceFarmaco
dc.titleHPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tabletsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractФранета, ЈТ; Aгбаба, Даница; Ерић, Славица; Aлексић, М.; Владимиров, С; Павков, С;
dc.citation.volume57
dc.citation.issue9
dc.citation.spage709
dc.citation.epage713
dc.citation.other57(9): 709-713
dc.citation.rankM23
dc.identifier.wos000178364100003
dc.identifier.doi10.1016/S0014-827X(02)01265-X
dc.identifier.pmid12385520
dc.identifier.scopus2-s2.0-0036754668
dc.type.versionpublishedVersion


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Приказ основних података о документу