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dc.creatorDejanović, Bratislav
dc.creatorVuković-Dejanović, Vesna
dc.creatorNinković, Milica
dc.creatorLavrnja, Irena
dc.creatorStojanović, Ivana
dc.creatorPavlović, Miloš
dc.creatorBegović, Vesna
dc.creatorMirković, Duško
dc.creatorStevanović, Ivana
dc.date.accessioned2019-09-02T12:07:57Z
dc.date.available2019-09-02T12:07:57Z
dc.date.issued2018
dc.identifier.issn0001-7213
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3222
dc.description.abstractThis study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% saline), chlorpromazine (38.7 mg/kg b.w.), chlorpromazine+agmatine (agmatine 75 mg/kg b.w. immediately after chlorpromazine, 38.7 mg/ kg b.w. i.p.) and agmatine (75 mg/kg b.w.) groups. All the tested substances were administered intraperitoneally for 15 consecutive days and the rats were sacrificed by decapitation on day 15. Subacute administration of chlorpromazine resulted in increased lipid peroxidation, nitric oxide concentration and superoxide anion production, while completely damaging the antioxidant defence system in the cerebral cortex, striatum, and hippocampus. However, the combined treatment with chlorpromazine and agmatine significantly attenuated the oxidative/nitrosative stress indices and restored the antioxidant capacity to the control values in all of the examined brain regions. Western blot analysis supported biochemical findings in all groups, but the most notable changes were found in the hippocampus. Our results suggest potentially beneficial effects of agmatine, which may be useful in the modified antioxidant approach in chlorpromazine-therapy.en
dc.publisherVeterinarni A Farmaceuticka Univerzita Brno, Brno
dc.relationMilitary Medical Academy, Republic of Serbia - MPhiBMA1/18-20
dc.rightsopenAccess
dc.sourceActa Veterinaria Brno
dc.subjectAntioxidant defenceen
dc.subjectbrainen
dc.subjectoxidative stressen
dc.titleEffects of agmatine on chlorpromazine-induced neuronal injury in raten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДејановић, Братислав; Мирковић, Душко; Стевановић, Ивана; Беговић, Весна; Павловић, Милош; Стојановић, Ивана; Лаврња, Ирена; Нинковић, Милица; Вуковић-Дејановић, Весна;
dc.citation.volume87
dc.citation.issue2
dc.citation.spage145
dc.citation.epage153
dc.citation.other87(2): 145-153
dc.citation.rankM23
dc.identifier.wos000438898800007
dc.identifier.doi10.2754/avb201887020145
dc.identifier.scopus2-s2.0-85049248429
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1802/3220.pdf
dc.identifier.rcubconv_4169
dc.type.versionpublishedVersion


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