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dc.creatorCirković, Ivana
dc.creatorJocić, Dario
dc.creatorBožić, Dragana
dc.creatorĐukić, Slobodanka
dc.creatorKonstantinović, Neda
dc.creatorRadak, Đorđe
dc.date.accessioned2019-09-02T12:08:03Z
dc.date.available2019-09-02T12:08:03Z
dc.date.issued2018
dc.identifier.issn1527-7941
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3225
dc.description.abstractBiofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P lt .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P lt .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175039/RS//
dc.rightsrestrictedAccess
dc.sourceAdvances in Skin & Wound Care
dc.subjectantibiofilm effecten
dc.subjectbiofilmen
dc.subjectdressing change frequencyen
dc.subjectmethicillin-resistant Staphylococcus aureusen
dc.subjectMRSAen
dc.subjectVAC therapyen
dc.subjectwound infectionen
dc.titleThe Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant Staphylococcus aureus Wound Biofilmsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈоцић, Дарио; Радак, Ђорђе; Константиновић, Неда; Божић, Драгана; Ђукић, Слободанка; Цирковић, Ивана;
dc.citation.volume31
dc.citation.issue8
dc.citation.spage361
dc.citation.epage364
dc.citation.other31(8): 361-364
dc.citation.rankM22
dc.identifier.wos000439942000005
dc.identifier.doi10.1097/01.ASW.0000540070.07040.70
dc.identifier.pmid30028372
dc.identifier.scopus2-s2.0-85050743021
dc.identifier.rcubconv_4180
dc.type.versionpublishedVersion


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