The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery R...N/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012.
TY - JOUR
AU - Mijušković, Mirjana
AU - Stanojević, Ivan
AU - Milović, Novak
AU - Cerović, Snežana
AU - Petrović, Dejan
AU - Maksić, Đoko
AU - Kovacević, Božidar
AU - Anđelić, Tamara
AU - Aleksić, Predrag
AU - Terzić, Brankica
AU - Đukić, Mirjana
AU - Vojvodić, Danilo
PY - 2018
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3231
AB - The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery RN/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012.
PB - Springer, Dordrecht
T2 - International Urology and Nephrology
T1 - Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma
VL - 50
IS - 1
SP - 63
EP - 70
DO - 10.1007/s11255-017-1724-6
ER -
@article{
author = "Mijušković, Mirjana and Stanojević, Ivan and Milović, Novak and Cerović, Snežana and Petrović, Dejan and Maksić, Đoko and Kovacević, Božidar and Anđelić, Tamara and Aleksić, Predrag and Terzić, Brankica and Đukić, Mirjana and Vojvodić, Danilo",
year = "2018",
abstract = "The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery RN/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma",
volume = "50",
number = "1",
pages = "63-70",
doi = "10.1007/s11255-017-1724-6"
}
Mijušković, M., Stanojević, I., Milović, N., Cerović, S., Petrović, D., Maksić, Đ., Kovacević, B., Anđelić, T., Aleksić, P., Terzić, B., Đukić, M.,& Vojvodić, D.. (2018). Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma. in International Urology and Nephrology
Springer, Dordrecht., 50(1), 63-70.
https://doi.org/10.1007/s11255-017-1724-6
Mijušković M, Stanojević I, Milović N, Cerović S, Petrović D, Maksić Đ, Kovacević B, Anđelić T, Aleksić P, Terzić B, Đukić M, Vojvodić D. Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma. in International Urology and Nephrology. 2018;50(1):63-70.
doi:10.1007/s11255-017-1724-6 .
Mijušković, Mirjana, Stanojević, Ivan, Milović, Novak, Cerović, Snežana, Petrović, Dejan, Maksić, Đoko, Kovacević, Božidar, Anđelić, Tamara, Aleksić, Predrag, Terzić, Brankica, Đukić, Mirjana, Vojvodić, Danilo, "Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma" in International Urology and Nephrology, 50, no. 1 (2018):63-70,
https://doi.org/10.1007/s11255-017-1724-6 . .
