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Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma
dc.creator | Mijušković, Mirjana | |
dc.creator | Stanojević, Ivan | |
dc.creator | Milović, Novak | |
dc.creator | Cerović, Snežana | |
dc.creator | Petrović, Dejan | |
dc.creator | Maksić, Đoko | |
dc.creator | Kovacević, Božidar | |
dc.creator | Anđelić, Tamara | |
dc.creator | Aleksić, Predrag | |
dc.creator | Terzić, Brankica | |
dc.creator | Đukić, Mirjana | |
dc.creator | Vojvodić, Danilo | |
dc.date.accessioned | 2019-09-02T12:08:12Z | |
dc.date.available | 2019-09-02T12:08:12Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0301-1623 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3231 | |
dc.description.abstract | The objective of this prospective follow-up trial was to ascertain whether the urinary kidney injury molecule-1 (uKIM-1) associates with tumor tissue (tKIM-1) expression and with the pathological characteristics of clear renal cell carcinoma (cRCC) in radically nephrectomized (RN) and/or in partially nephrectomized (PN) patients with cRCC, pre- and postoperatively. This clinical study included 40 patients subjected to RN/PN (cRCC group) and 30 healthy volunteers (control group). Urinary KIM-1 was determined by ELISA TIM-1/KIM-1 kit and normalized by urinary creatinine. Immunohistochemical staining (monoclonal anti-human anti-TIM-1/KIM-1/HAVCR antibody) was used for semiquantitative analysis of the tKIM-1 expression and expressed as a score (% KIM-1 positively stained tubules). Both markers were interpreted in terms of the tumor characteristics comprising tumor size, Fuhrman grade, pathological (pT) stage, tumor/nodes/metastasis (TNM) stage, lymphovascular invasion and type of surgery RN/PN. Preoperative uKIM-1 was significantly higher in the cRCC group compared to controls, such as uKIM-1 was statistically higher in RN than in PN patients. Postoperatively, uKIM-1 decreased to control values. Expression of tKIM-1 was documented in all nephrectomized patients. Significant associations were achieved between uKIM-1 and tKIM-1 and with considered tumor characteristics, especially with tumor size and grade. Based on the accomplished associations, we found uKIM-1 as a highly sensitive marker for cRCC diagnosis. The clinical trial registration number: 1110-2012. | en |
dc.publisher | Springer, Dordrecht | |
dc.relation | Ministry of Defense of the Republic of Serbia (Project no. MFVMA/3/13-15) | |
dc.rights | restrictedAccess | |
dc.source | International Urology and Nephrology | |
dc.subject | Disease markers | en |
dc.subject | KIM-1 | en |
dc.subject | Kidney | en |
dc.subject | Nephrectomy | en |
dc.subject | Clear renal cell carcinoma | en |
dc.subject | Tumors | en |
dc.title | Tissue and urinary KIM-1 relate to tumor characteristics in patients with clear renal cell carcinoma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станојевић, Иван; Церовић, Снежана; Максић, Ђоко; Ковацевић, Божидар; Aлексић, Предраг; Aнђелић, Тамара; Терзић, Бранкица; Војводић, Данило; Петровић, Дејан; Ђукић, Мирјана; Миловић, Новак; Мијушковић, Мирјана; | |
dc.citation.volume | 50 | |
dc.citation.issue | 1 | |
dc.citation.spage | 63 | |
dc.citation.epage | 70 | |
dc.citation.other | 50(1): 63-70 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000419704800010 | |
dc.identifier.doi | 10.1007/s11255-017-1724-6 | |
dc.identifier.pmid | 29052086 | |
dc.identifier.scopus | 2-s2.0-85031827150 | |
dc.type.version | publishedVersion |