Show simple item record

dc.creatorKlisić, Aleksandra
dc.creatorKavarić, Nebojša
dc.creatorBjelaković, Bojko
dc.creatorJovanović, Milovan
dc.creatorZvrko, Elvir
dc.creatorStanišić, Verica
dc.creatorNinić, Ana
dc.creatorŠćepanović, Anđelka
dc.date.accessioned2019-09-02T12:08:25Z
dc.date.available2019-09-02T12:08:25Z
dc.date.issued2018
dc.identifier.issn0353-9466
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3239
dc.description.abstractReynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.en
dc.publisherSestre Milosrdnice Univ Hospital, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceActa Clinica Croatica
dc.subjectCardiovascular diseasesen
dc.subjectRisk factorsen
dc.subjectBody mass indexen
dc.subjectWaist circumferenceen
dc.subjectC-reactive proteinen
dc.subjectObesityen
dc.subjectCause of deathen
dc.subjectMontenegroen
dc.titleCardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegroen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractКаварић, Небојша; Клисић, Aлександра; Станишић, Верица; Бјелаковић, Бојко; Нинић, Aна; Јовановић, Милован; Зврко, Елвир; Шћепановић, Aнђелка;
dc.citation.volume57
dc.citation.issue1
dc.citation.spage22
dc.citation.epage30
dc.citation.other57(1): 22-30
dc.citation.rankM23
dc.identifier.wos000436502400003
dc.identifier.doi10.20471/acc.2018.57.01.03
dc.identifier.pmid30256008
dc.identifier.scopus2-s2.0-85048725065
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1815/3237.pdf
dc.identifier.rcubconv_4144
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record