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High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate

Authorized Users Only
2002
Authors
Milojević, Z
Agbaba, Danica
Erić, Slavica
Boberić-Borojević, D
Ristić, P
Solujić, M
Article (Published version)
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Abstract
A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple an...d accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.

Source:
Journal of Chromatography A, 2002, 949, 1-2, 79-82
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/S0021-9673(01)01510-2

ISSN: 0021-9673

PubMed: 11999760

WoS: 000174633300010

Scopus: 2-s2.0-0037040560
[ Google Scholar ]
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URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/325
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Milojević, Z
AU  - Agbaba, Danica
AU  - Erić, Slavica
AU  - Boberić-Borojević, D
AU  - Ristić, P
AU  - Solujić, M
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/325
AB  - A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple and accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography A
T1  - High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate
VL  - 949
IS  - 1-2
SP  - 79
EP  - 82
DO  - 10.1016/S0021-9673(01)01510-2
ER  - 
@article{
author = "Milojević, Z and Agbaba, Danica and Erić, Slavica and Boberić-Borojević, D and Ristić, P and Solujić, M",
year = "2002",
abstract = "A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple and accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography A",
title = "High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate",
volume = "949",
number = "1-2",
pages = "79-82",
doi = "10.1016/S0021-9673(01)01510-2"
}
Milojević, Z., Agbaba, D., Erić, S., Boberić-Borojević, D., Ristić, P.,& Solujić, M.. (2002). High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. in Journal of Chromatography A
Elsevier Science BV, Amsterdam., 949(1-2), 79-82.
https://doi.org/10.1016/S0021-9673(01)01510-2
Milojević Z, Agbaba D, Erić S, Boberić-Borojević D, Ristić P, Solujić M. High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. in Journal of Chromatography A. 2002;949(1-2):79-82.
doi:10.1016/S0021-9673(01)01510-2 .
Milojević, Z, Agbaba, Danica, Erić, Slavica, Boberić-Borojević, D, Ristić, P, Solujić, M, "High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate" in Journal of Chromatography A, 949, no. 1-2 (2002):79-82,
https://doi.org/10.1016/S0021-9673(01)01510-2 . .

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