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dc.creatorNacka-Aleksić, Mirjana
dc.creatorPilipović, Ivan
dc.creatorKotur-Stevuljević, Jelena
dc.creatorPetrović, Raisa
dc.creatorSopta, Jelena
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T12:08:49Z
dc.date.available2019-09-02T12:08:49Z
dc.date.issued2019
dc.identifier.issn1389-5729
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3256
dc.description.abstractThe study investigated mechanisms underlying sex differences in thymic involution in Dark Agouti rats. Adverse effects of aging on thymus were more pronounced in males than in females. Thymi from old males exhibited more prominent: (i) fibro-adipose degeneration which correlated with greater intensity of thymic oxidative stress and enhanced thymic TGF- and IL-6 expression and (ii) decline in thymopoiesis, as suggested by the number of the most mature CD4+CD8-/CD4-CD8+ single positive (SP) TCRhigh thymocytes. The greater accumulation of adipose tissue in old male thymus was linked with greater age-related increase in thymic expression of PPAR and STAT3, a transcription factor regulating the expression of PPAR downstream genes, in male than in female rats. In aged thymi of both sexes the early CD4-CD8- double negative (DN) stage of thymocyte development was affected, so relative accumulation of the least mature CD45RC+CD2- cells followed by decreased frequency of their DN and CD4+CD8+ double positive (DP) TCR- descendants was observed. Additionally, in old males, because of the increased thymic expression of Nur77, a nuclear receptor involved in negative selection, and decreased CD90 (a negative regulator of thymocyte selection threshold) MFI on DP TCRint thymocytes, less efficient positive/more efficient negative selection was found. Moreover, in male rats, thymocyte post-selection differentiation/maturation was skewed towards CD4-CD8+ SP TCRhigh cells compared with age-matched females, reflecting, at least partly, greater IL-15 expression in their thymi. The study indicated mechanisms underlying sex-based differences in age-related thymic changes and consequently necessity of sex-specific approaches in designing strategies to rejuvenate thymus.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceBiogerontology
dc.subjectAgingen
dc.subjectSex differencesen
dc.subjectFibro-adipose thymic involutionen
dc.subjectThymopoiesisen
dc.subjectThymic inflammatoryen
dc.subjectredox stateen
dc.titleSexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПетровић, Раиса; Пилиповић, Иван; Котур-Стевуљевић, Јелена; Лепосавић, Гордана; Нацка-Aлексић, Мирјана; Сопта, Јелена;
dc.citation.volume20
dc.citation.issue4
dc.citation.spage545
dc.citation.epage569
dc.citation.other20(4): 545-569
dc.citation.rankM21
dc.identifier.wos000472839400012
dc.identifier.doi10.1007/s10522-019-09816-3
dc.identifier.pmid31119497
dc.identifier.scopus2-s2.0-85066913111
dc.identifier.rcubconv_4410
dc.type.versionpublishedVersion


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