Show simple item record

dc.creatorLazić, Vesna
dc.creatorVukoje, Ivana
dc.creatorMilicević, Bojana
dc.creatorPotparević, Biljana
dc.creatorŽivković, Lada
dc.creatorTopalović, Dijana
dc.creatorBajić, Vladan
dc.creatorSredojević, Dušan
dc.creatorNedeljković, Jovan M.
dc.date.accessioned2019-09-02T12:08:51Z
dc.date.available2019-09-02T12:08:51Z
dc.date.issued2019
dc.identifier.issn0352-5139
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3257
dc.description.abstractThe genotoxic and antigenotoxic behavior of the interfacial charge transfer (ICT) complex between nano-sized TiO2 particles and caffeic acid (CA) was studied in in vitro experiments. The formation of the ICT complex is indicated by the appearance of absorption in visible-spectral range. The continual variations method indicated bridging coordination between the ligand, caffeic acid, and the surface Ti atoms, while the stability constant of the ICT complex was found to be 1.5x10(3) mol(-1) L. An agreement between the experimental data and the theoretical results, based on the density functional theory, was found. The ICT complex and its components did not display genotoxicity in the broad concentration range 0.4. 8.0 mg mL(-1) TiO2 at a mole ratio c(TiO2)/c(CA) = 8. On the other hand, post-treatment of damaged DNA by the ICT complex induced antigenotoxic effect at lower concentrations, but at higher concentrations, 5.125-10.250 mg mL(-1) ICT, the ICT complex did not show any beneficial effect on H2O2-induced DNA damaged cells. The experimental data were analyzed using the combinatorial method to determine the effect of component interaction on the genotoxic and antigenotoxic behavior of the ICT complex.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45020/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjecthybrid nanomaterialsen
dc.subjectDFT calculationen
dc.subjectgenotoxic propertyen
dc.subjectantigenotoxic propertyen
dc.titleEfficiency of the interfacial charge transfer complex between TiO2 nanoparticles and caffeic acid against DNA damage in vitro: A combinatorial analysisen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСредојевић, Душан; Живковић, Лада; Лазић, Весна; Недељковић, Јован М.; Потпаревић, Биљана; Топаловић, Дијана; Вукоје, Ивана; Бајић, Владан; Милицевић, Бојана;
dc.citation.volume84
dc.citation.issue6
dc.citation.spage539
dc.citation.epage553
dc.citation.other84(6): 539-553
dc.citation.rankM23
dc.identifier.wos000474347000002
dc.identifier.doi10.2298/JSC181217017L
dc.identifier.scopus2-s2.0-85071274640
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1834/3255.pdf
dc.identifier.rcubconv_4430
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record