Приказ основних података о документу

dc.creatorAlbert, Lea
dc.creatorPenalver, Alberto
dc.creatorĐoković, Nemanja
dc.creatorWerel, Laura
dc.creatorHoffarth, Malte
dc.creatorRužić, Dušan
dc.creatorXu, Jing
dc.creatorEssen, Lars-Oliver
dc.creatorNikolić, Katarina
dc.creatorDou, Yali
dc.creatorVazquez, Olalla
dc.date.accessioned2019-09-02T12:08:54Z
dc.date.available2019-09-02T12:08:54Z
dc.date.issued2019
dc.identifier.issn1439-4227
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3258
dc.description.abstractLife relies on a myriad of carefully orchestrated processes, in which proteins and their direct interplay ultimately determine cellular function and disease. Modulation of this complex crosstalk has recently attracted attention, even as a novel therapeutic strategy. Herein, we describe the synthesis and characterization of two visible-light-responsive peptide backbone photoswitches based on azobenzene derivatives, to exert optical control over protein-protein interactions (PPI). The novel peptidomimetics undergo fast and reversible isomerization with low photochemical fatigue under alternatively blue-/green-light irradiation cycles. Both bind in the nanomolar range to the protein of interest. Importantly, the best peptidomimetic displays a clear difference between isomers in its protein-binding capacity and, in turn, in its potential to inhibit enzymatic activity through PPI disruption. In addition, crystal structure determination, docking and molecular dynamics calculations allow a molecular interpretation and open up new avenues in the design and synthesis of future photoswitchable PPI modulators.en
dc.publisherWiley-VCH Verlag GMBH, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171017/RS//
dc.rightsrestrictedAccess
dc.sourceChembiochem
dc.subjectazobenzenesen
dc.subjectisomerizationen
dc.subjectpeptidomimeticsen
dc.subjectphotochemistryen
dc.subjectprotein-protein interactionsen
dc.titleModulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitchesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAлберт, Леа; Ружић, Душан; Николић, Катарина; Xу, Јинг; Хоффартх, Малте; Вазqуез, Олалла; Wерел, Лаура; Пеналвер, Aлберто; Ђоковић, Немања; Ессен, Ларс-Оливер; Доу, Yали;
dc.citation.volume20
dc.citation.issue11
dc.citation.spage1417
dc.citation.epage1429
dc.citation.other20(11): 1417-1429
dc.citation.rankM22
dc.identifier.wos000474071700012
dc.identifier.doi10.1002/cbic.201800737
dc.identifier.pmid30675988
dc.identifier.scopus2-s2.0-85065047737
dc.type.versionpublishedVersion


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Приказ основних података о документу