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dc.creatorMilojević, Z
dc.creatorAgbaba, Danica
dc.creatorErić, Slavica
dc.creatorBoberić-Borojević, D
dc.creatorRistić, P
dc.creatorSolujić, M
dc.date.accessioned2019-09-02T10:54:12Z
dc.date.available2019-09-02T10:54:12Z
dc.date.issued2002
dc.identifier.issn0021-9673
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/325
dc.description.abstractA rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple and accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.titleHigh-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoateen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилојевић, З; Aгбаба, Даница; Ерић, Славица; Ристић, П; Солујић, М; Боберић-Боројевић, Д;
dc.citation.volume949
dc.citation.issue1-2
dc.citation.spage79
dc.citation.epage82
dc.citation.other949(1-2): 79-82
dc.citation.rankaM21
dc.identifier.wos000174633300010
dc.identifier.doi10.1016/S0021-9673(01)01510-2
dc.identifier.pmid11999760
dc.identifier.scopus2-s2.0-0037040560
dc.identifier.rcubconv_1356
dc.type.versionpublishedVersion


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