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Propranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitis
dc.creator | Pilipović, Ivan | |
dc.creator | Vujnović, Ivana | |
dc.creator | Petrović, Raisa | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T12:09:01Z | |
dc.date.available | 2019-09-02T12:09:01Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1021-7401 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3263 | |
dc.description.abstract | Objective: We examined the effect of β-adrenoceptor (AR) blockade in the preclinical phase of experimental autoimmune encephalomyelitis (EAE), the most commonly used model of multiple sclerosis, on the development of primary CD4+ T-cell responses in draining lymph nodes (dLNs). Methods: CD11b+ cell migration to dLNs, CD4+ T-cell activation/proliferation, and IL-17+ CD4+ (Th17) cell numbers in dLN and spinal cord (SC) were examined in male and female Dark Agouti rats using flow cytometry analysis. Results: Irrespective of sex, in propranolol-treated (PT) rats, migration of CD11b+ antigen-presenting cells from the site of immunization to dLNs was impaired compared with saline-treated controls and consequently the frequency of all CD11b+ cells in dLNs and activated cells among them, too. This correlated with decreased expression of CCL19/21 transcripts in dLNs. Consistently, the frequency of activated/proliferating cells among dLN CD4+ T cells was reduced in PT rats. Additionally, propranolol reduced the number of Th17 cells in dLNs and SC. Consistently, male and female PT rats exhibited a decreased incidence of EAE and prolonged duration of the asymptomatic disease phase. Conclusion: This study suggests that sympathetic dysregulation is involved in the outbreak of clinical EAE. | en |
dc.publisher | S. Karger AG | |
dc.rights | restrictedAccess | |
dc.source | NeuroImmunoModulation | |
dc.title | Propranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Петровић, Раиса; Пилиповић, Иван; Стојић-Вуканић, Зорица; Вујновић, Ивана; Лепосавић, Гордана; | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000481456200003 | |
dc.identifier.doi | 10.1159/000500094 | |
dc.identifier.scopus | 2-s2.0-85066936523 | |
dc.type.version | publishedVersion |
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