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Validation of a high-performance liquid chromatography method for the determination of pancuronium in Pavulon injections

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2002
Authors
Zečević, Mira
Živanović, L
Stojković, A
Article (Published version)
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Abstract
A new high-performance liquid chromatography (HPLC) method was developed for the quality control of pancuronium bromide and its degradation products. The HPLC method used a 5-mum Supelcogel ODP-50 (150X4 cm) column with acetonitrile-CH3OH-water-F3CCOOH (20.5:74.9:0.1, v/v) as the mobile phase (pH value 2.0 adjusted with trifluoroacetic acid) at a flow-rate 0.8 ml/min and UV detection at 210 nm. The Beer's law plots were found to be linear over the concentration range 0.4-1.2 mg/ml of pancuronium bromide and 0.04-0.08 mg/ml of desacetyl degradation products (R-2=0.9995). The RSD of the peak areas was 1.09% and the recovery was 102.43%. The RSD value shows good precision, acceptable accuracy and reproducibility of the new method for the determination of pancuronium bromide in presence of its desacetyl degradation products. The method is rapid and sensitive enough to be used for Pavulon injection analysis. 2002 Elsevier Science B.V. All rights reserved.
Source:
Journal of Chromatography A, 2002, 949, 1-2, 61-64
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/S0021-9673(01)01552-7

ISSN: 0021-9673

PubMed: 11999757

WoS: 000174633300007

Scopus: 2-s2.0-0037040588
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/327
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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